UFM1 and DIABLO

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UFM1	DIABLO
Gene Name		ubiquitin-fold modifier 1	diablo, IAP-binding mitochondrial protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function		Protein Binding
	Biological Process	Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Protein Ufmylation Protein Polyufmylation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response SMAC binds to IAPs Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARHGDIA ARHGDIB DIABLO GSK3B RPS6KA6 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W UFC1	20 interactors: AREL1 ARL6IP1 ARNT BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 EEF1A1 HTRA2 LTBR MAML2 NGFRAP1 NR4A1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		51569	56616
HPRD ID		15644	05560
Ensembl ID		ENSG00000120686	ENSG00000184047
Uniprot IDs		P61960	K7X1S0 Q502X2 Q9NR28
PDB IDs		1WXS	1FEW 1G3F 1G73 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein Ubiquitination Cellular Response To Stress Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Protein Polyufmylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Ufmylation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Response To Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Protein Ubiquitination Negative Regulation Of Protein Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Necroptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Signaling Intracellular Signal Transduction Protein Metabolic Process Regulation Of Neuron Death
Tagcloud ?		17beta abrogated activating asc1 bound coactivator displaced e1 e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation uba5 ufmylation ufsp2	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Difference) ?		17beta abrogated activating asc1 bound coactivator displaced e1 e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation uba5 ufmylation ufsp2	angiogen angioprevention argeting attributes b2g2 ccm cdc2 cdc25c cdks conditioned esis gallate grape hallmarks hile howed hpmecs huvecs invasiveness ngioprevention normoxic o2 pc3 phytochemicals procyanidin smac tube vegfr2 warrants
Tagcloud (Intersection) ?