ETS1 and MAF

Number of citations: 66 (PubMedID 9566892)
Data Source: HPRD (in vitro)

		ETS1	MAF
Name		ETS proto-oncogene 1, transcription factor	MAF bZIP transcription factor
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling
Pathways		Oncogene Induced Senescence	RUNX2 regulates osteoblast differentiation
Diseases		None	Multiple myeloma
GWAS		Adverse response to drug ( 30420678 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 32296059 30929738 ) Asthma (childhood onset) ( 30929738 ) Atopic dermatitis ( 26482879 ) Celiac disease ( 20190752 22057235 25920553 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Depressive and manic episodes in bipolar disorder ( 26297903 ) Depressive episodes in bipolar disorder ( 26297903 ) Eczema ( 31361310 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Fasting glucose ( 34059833 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Follicular lymphoma ( 25279986 ) Glaucoma ( 31959993 30054594 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 33627673 ) Granulocyte count ( 27863252 ) Height ( 31562340 ) Inflammatory bowel disease ( 28067908 ) Intraocular pressure ( 31959993 30054594 29785010 29617998 ) Itch intensity from mosquito bite ( 28199695 ) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882 ) Lung function (FVC) ( 30061609 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Manganese levels ( 26025379 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte count ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 31604244 24076602 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 27863252 ) Plateletcrit ( 27863252 32888494 ) Psoriasis ( 25903422 23143594 ) Psoriasis vulgaris ( 26626624 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 24390342 30423114 22446963 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Self-reported allergy ( 23817569 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301 ) Triglyceride levels in HIV infection ( 33109212 ) Type 2 diabetes ( 30718926 30297969 30054458 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 27863252 32888494 )	Alanine aminotransferase levels ( 34315874 33547301 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Colorectal cancer ( 31826910 30529582 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 20668459 ) High density lipoprotein cholesterol levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lysophosphatidylcholine levels ( 31551469 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 24076602 21833088 31604244 ) Obesity ( 19151714 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Refractive error ( 32231278 ) Renal function-related traits (urate) ( 22797727 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Serum alkaline phosphatase levels ( 29403010 33547301 33339817 ) Serum thyroid-stimulating hormone levels ( 24852370 ) Serum uric acid levels ( 30993211 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Thyroid volume ( 21565293 ) Triglyceride levels ( 32203549 ) Urate levels ( 31985003 23263486 ) Vitamin C levels ( 33203707 )
Interacting Genes		54 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6	16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2
Entrez ID		2113	4094
HPRD ID		01260	01518
Ensembl ID		ENSG00000134954	ENSG00000178573
Uniprot IDs		A8K725 B4DW78 P14921	H3BP11 O75444
PDB IDs		1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway	Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels