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ETS1 and STAT6
Number of citations of the paper that reports this interaction (PubMedID
15199062
)
0
Data Source:
HPRD
(in vivo)
ETS1
STAT6
Description
ETS proto-oncogene 1, transcription factor
signal transducer and activator of transcription 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nucleic Acid Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Phosphatase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Biological Process
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Immune Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Cell Differentiation
PML Body Organization
Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Response To Antibiotic
Cell Motility
Positive Regulation Of Inflammatory Response
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Negative Regulation Of Transcription By RNA Polymerase II
T-helper 1 Cell Lineage Commitment
Negative Regulation Of Type 2 Immune Response
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Gene Expression
Cytokine-mediated Signaling Pathway
Mammary Gland Epithelial Cell Proliferation
Interleukin-4-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Peptide Hormone
Positive Regulation Of Transcription By RNA Polymerase II
Isotype Switching To IgE Isotypes
Positive Regulation Of Isotype Switching To IgE Isotypes
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Mammary Gland Morphogenesis
Regulation Of Mast Cell Proliferation
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Oncogene Induced Senescence
Downstream signal transduction
STAT6-mediated induction of chemokines
Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS
Adverse response to drug (
30420678
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Atopic dermatitis (
26482879
)
Celiac disease (
20190752
22057235
25920553
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Depressive and manic episodes in bipolar disorder (
26297903
)
Depressive episodes in bipolar disorder (
26297903
)
Eczema (
31361310
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Fasting glucose (
34059833
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Follicular lymphoma (
25279986
)
Glaucoma (
31959993
30054594
)
Glaucoma (multi-trait analysis) (
31959993
)
Glaucoma (primary open-angle) (
33627673
)
Granulocyte count (
27863252
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Intraocular pressure (
31959993
30054594
29785010
29617998
)
Itch intensity from mosquito bite (
28199695
)
Liver fibrosis in pediatric non-alcoholic fatty acid liver disease (
28918882
)
Lung function (FVC) (
30061609
)
Lymphocyte count (
32888494
27863252
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Manganese levels (
26025379
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
27863252
32888494
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
24076602
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
27863252
)
Plateletcrit (
27863252
32888494
)
Psoriasis (
25903422
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Rheumatoid arthritis (
24390342
30423114
22446963
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Self-reported allergy (
23817569
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
19838193
20169177
23273568
28714469
27399966
26502338
26663301
)
Triglyceride levels in HIV infection (
33109212
)
Type 2 diabetes (
30718926
30297969
30054458
)
Ulcerative colitis (
28067908
)
White blood cell count (
27863252
32888494
)
Adult asthma (
30787307
)
Alcohol consumption (
31358974
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31619474
31361310
31959851
30929738
32296059
29273806
34103634
27182965
)
Asthma (adult onset) (
30929738
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma (moderate or severe) (
30552067
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
31043756
)
Bitter alcoholic beverage consumption (
31046077
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Eosinophilic esophagitis (
25407941
)
Eosinophilic esophagitis (pediatric) (
20208534
)
Familial lung cancer (
29924316
)
Headache (
29397368
)
Height (
31562340
)
IgE levels (
22075330
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Medication use (adrenergics, inhalants) (
31015401
)
Medication use (anti-inflammatory and antirheumatic products, non-steroids) (
31015401
)
Medication use (antihistamines for systemic use) (
31015401
)
Migraine (
27322543
)
Migraine without aura (
27322543
)
Mosquito bite size (
28199695
)
Neutrophil percentage of granulocytes (
27863252
)
Perceived unattractiveness to mosquitoes (
28199695
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Sensory disturbances after bilateral sagittal split ramus osteotomy (
23834954
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
54 interacting genes:
APLP2
APP
ARID4B
ARL6IP4
ATF2
BRCA1
CAMK2A
CAMK2B
COP1
CREB1
CREBBP
CYBC1
DAXX
DNMT3L
EIF5B
EP300
ETS2
FOS
GATA3
GGA1
GGA2
GGA3
HTATIP2
JUN
MAF
MAPK1
MAPK3
MAPK7
MED23
MEIS1
NCL
NCOR1
NFKB1
NR3C1
PARP1
PAX5
POU1F1
RBBP6
RPL13A
RUNX1T1
RUNX2
SMAD3
SP1
SP100
SPI1
SRA1
SRC
SRSF11
STAT5B
STAT6
TBP
TDP2
UBE2I
XRCC6
39 interacting genes:
ANKZF1
ANXA2
CEBPB
CEBPE
CEBPZ
CREBBP
DAZAP2
EEF1A1
EP300
ETS1
FBXO7
H3C14
IFNG
IL4R
IRF4
JAK1
LITAF
NCOA1
NCOA2
NFKB1
NMI
PKNOX1
PPARG
PRKCZ
PTPN6
RCN3
RELA
RLIM
SND1
SRC
STAT2
STAT3
TP53
TRIM24
VKORC1
WWP1
ZBTB2
ZNF407
ZNF92
Entrez ID
2113
6778
HPRD ID
01260
03302
Ensembl ID
ENSG00000134954
ENSG00000166888
Uniprot IDs
A8K725
B4DW78
P14921
A8K4S9
B4DQB3
P42226
PDB IDs
1GVJ
2NNY
2STT
2STW
3MFK
3RI4
3WTS
3WTT
3WTU
3WTV
3WTW
3WTX
3WTY
3WTZ
3WU0
3WU1
4L0Y
4L0Z
4L18
4LG0
5ZMC
1OJ5
4Y5U
4Y5W
5D39
5NWM
5NWX
9BIG
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Regulation Of Gene Expression
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Transcription Cis-regulatory Region Binding
Negative Regulation Of Biosynthetic Process
Nucleoplasm
Chromatin
Transcription Regulator Complex
Negative Regulation Of Metabolic Process
Response To Growth Factor
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Identical Protein Binding
Nucleus
Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity
DNA-templated Transcription
Cellular Response To Growth Factor Stimulus
Regulation Of MiRNA Transcription
Transcription By RNA Polymerase II
Transcription Coactivator Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Sequence-specific DNA Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Transcription By RNA Polymerase II
Chromatin
Regulation Of Immune System Process
Nucleobase-containing Compound Biosynthetic Process
Chromatin Binding
Nucleus
RNA Polymerase II Transcription Regulator Complex
Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Defense Response
Transcription Regulator Complex
RNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Defense Response
MRNA Transcription
DNA Binding
Positive Regulation Of MiRNA Metabolic Process
T Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Multicellular Organismal Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
T-helper 17 Cell Lineage Commitment
DNA-binding Transcription Factor Activity
Negative Regulation Of Biosynthetic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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