GULP1 and LRP1

Number of citations of the paper that reports this interaction (PMID 11729193)
54

Data Source:
HPRD (in vivo, in vitro)

		GULP1	LRP1
Gene Name		GULP, engulfment adaptor PTB domain containing 1	low density lipoprotein receptor-related protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Signal Transducer Activity	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Transport Phagocytosis, Engulfment Apoptotic Process Signal Transduction	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		4 interactors: CREB3L2 EPS8 LRP1 SMC2	63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		51454	4035
HPRD ID		12181	00138
Ensembl ID			ENSG00000123384
Uniprot IDs		Q9UBP9	Q07954 Q59FG2
PDB IDs			1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Actin Polymerization-dependent Cell Motility Mitotic Nuclear Division Exit From Mitosis Regulation Of Actin Cytoskeleton Organization Behavioral Response To Ethanol Meiotic Chromosome Condensation Regulation Of Actin Filament-based Process Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Rac Protein Signal Transduction Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Lipoprotein Transport Positive Regulation Of Cholesterol Transport Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Regulation Of Cholesterol Efflux Aorta Morphogenesis Mitotic Chromosome Condensation Mitotic Cell Cycle Process Aorta Development Kinetochore Organization Cell Proliferation Apoptotic Cell Clearance Mitotic Cell Cycle Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell
Tagcloud ?		adaptor adaptors additionally another app binds characterize differential engulfment fe65 functionally influencing intracellular lipoprotein lrp1 mediate mediates motifs npxy phosphotyrosine plasmid precursor ptb reporter signalling supported thereby trafficking transactivation	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		adaptor adaptors additionally another app binds characterize differential engulfment fe65 functionally influencing intracellular lipoprotein mediate mediates motifs npxy phosphotyrosine plasmid precursor ptb reporter signalling supported thereby trafficking transactivation	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?		lrp1