GULP1 and SMC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GULP1	SMC2
Description		GULP PTB domain containing engulfment adaptor 1	structural maintenance of chromosomes 2
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GO Annotations	Cellular Component	Cytoplasm	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function		Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Lipid Transport Phagocytosis Phagocytosis, Engulfment Apoptotic Process	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways			Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)
Interacting Genes		6 interacting genes: CREB3L2 EPS8 LRP1 MEGF10 SMC2 SNCA	11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1
Entrez ID		51454	10592
HPRD ID		12181	09277
Ensembl ID		ENSG00000144366	ENSG00000136824
Uniprot IDs		A0A8V8TQW5 H7BZV7 Q9UBP9	A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs		6ITU	4U4P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Scavenger Receptor Activity Apoptotic Cell Clearance Positive Regulation Of Cellular Component Organization Adult Locomotory Behavior Regulation Of Organelle Organization Receptor Internalization Positive Regulation Of Transcytosis Vesicle-mediated Transport Endocytosis Positive Regulation Of Protein Localization To Cell Periphery Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phagocytosis Regulation Of Cytoskeleton Organization Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Growth Cone Negative Regulation Of Protein-containing Complex Assembly Import Into Cell Cell Activation Lipoprotein Particle Receptor Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Adult Behavior Positive Regulation Of Endocytosis Regulation Of Protein Localization To Cell Periphery Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Myoblast Development Receptor-mediated Endocytosis Cell Cortex Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Skeletal Muscle Satellite Cell Proliferation	Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle
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