SNX9 and CLTC

Number of citations of the paper that reports this interaction (PMID 12952949)
36

Data Source:
HPRD (in vivo, in vitro)

		SNX9	CLTC
Gene Name		sorting nexin 9	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Protein Homodimerization Activity Arp2/3 Complex Binding	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Mitotic Nuclear Division Vesicle Organization Endosomal Transport Positive Regulation Of Protein Oligomerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Tubulation	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ADAM15 ADAM9 CLTC DNM1 DNM2 FASLG ITCH KHDRBS1 MPHOSPH6 MPP6 PAK2 SOS1 SOS2 TNK2 WASL	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		51429	1213
HPRD ID		12072	00350
Ensembl ID		ENSG00000130340	ENSG00000141367
Uniprot IDs		Q9Y5X1	Q00610
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Internalization Cell Morphogenesis Involved In Differentiation Axon Guidance Signal Transduction Cell Development Response To External Stimulus Locomotion Innate Immune Response Immune Response Neuron Projection Development Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Axonogenesis Neuron Development Receptor Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Cell Death Regulation Of Catalytic Activity Endocytosis Anatomical Structure Morphogenesis Neuron Differentiation Cellular Response To Stimulus Cell Projection Organization Developmental Process Positive Regulation Of Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Defense Response Nitric Oxide Metabolic Process Regulation Of Apoptotic Process	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?