SNX9 and ADAM15

Number of citations of the paper that reports this interaction (PMID 10531379)
35

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SNX9	ADAM15
Gene Name		sorting nexin 9	ADAM metallopeptidase domain 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Protein Homodimerization Activity Arp2/3 Complex Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Mitotic Nuclear Division Vesicle Organization Endosomal Transport Positive Regulation Of Protein Oligomerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Tubulation	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		15 interactors: ADAM15 ADAM9 CLTC DNM1 DNM2 FASLG ITCH KHDRBS1 MPHOSPH6 MPP6 PAK2 SOS1 SOS2 TNK2 WASL	32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		51429	8751
HPRD ID		12072	05674
Ensembl ID		ENSG00000130340	ENSG00000143537
Uniprot IDs		Q9Y5X1	B4DMH8 Q13444 U3KQL5
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
Enriched GO Terms of Interacting Partners?		Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Internalization Cell Morphogenesis Involved In Differentiation Axon Guidance Signal Transduction Cell Development Response To External Stimulus Locomotion Innate Immune Response Immune Response Neuron Projection Development Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Axonogenesis Neuron Development Receptor Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Cell Death Regulation Of Catalytic Activity Endocytosis Anatomical Structure Morphogenesis Neuron Differentiation Cellular Response To Stimulus Cell Projection Organization Developmental Process Positive Regulation Of Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Defense Response Nitric Oxide Metabolic Process Regulation Of Apoptotic Process	Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?