SNX9 and PIK3R5

Number of citations of the paper that reports this interaction (PubMedID 17242350)
58

Data Source:
BioGRID (pull down)

		SNX9	PIK3R5
Description		sorting nexin 9	phosphoinositide-3-kinase regulatory subunit 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cuticular Plate Cell Projection Extracellular Exosome Presynapse	Nucleus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane Centriolar Satellite
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Lipid Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation Regulation Of Synaptic Vesicle Endocytosis	Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS
Drugs
Diseases
GWAS		Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494)	Atypical femoral fracture in phosphonate treatment ( 31006051) Autoimmune thyroid disease ( 32581359) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		25 interacting genes: ADAM15 ADAM9 AP1G1 CEBPA CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MECOM MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL	5 interacting genes: APP CFTR PIK3CG SDHB SNX9
Entrez ID		51429	23533
HPRD ID		12072	11433
Ensembl ID		ENSG00000130340	ENSG00000141506
Uniprot IDs		Q9Y5X1	J3KSW1 L7RT34 Q8WYR1
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE 7OJ9
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Plasma Membrane Clathrin-coated Pit Vesicle Budding From Membrane Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Endocytosis Immune System Process Clathrin-coated Vesicle Phosphatidylinositol 3-kinase Complex, Class IB Import Into Cell Intracellular Signaling Cassette Kinase Activity Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Focal Adhesion Regulation Of Hematopoietic Progenitor Cell Differentiation Cytosol Regulation Of Immune System Process Phosphatidylinositol 3-kinase Complex Regulation Of Pro-B Cell Differentiation Regulation Of Cellular Component Organization Extracellular Exosome Phosphatidylinositol 3-kinase Complex, Class IA Cytoplasm Actin Filament-based Movement Epidermal Growth Factor Receptor Signaling Pathway Transferrin Transport Receptor-mediated Endocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphoid Progenitor Cell Differentiation Protein Serine Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Receptor Internalization Cellular Response To Type II Interferon Vesicle-mediated Transport Regulation Of ERBB Signaling Pathway Regulation Of Protein Metabolic Process Protein Polymerization Eyelid Development In Camera-type Eye ERBB Signaling Pathway Insulin Receptor Signaling Pathway Apoptotic Process Regulation Of Macromolecule Metabolic Process	Cellular Response To CAMP Response To CAMP Response To Purine-containing Compound Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Blood Circulation Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Monoatomic Ion Transport Endocytosis Clathrin-coated Pit Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-folding Chaperone Binding Regulation Of Phosphorus Metabolic Process Regulation Of Transport Import Into Cell Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Natural Killer Cell Chemotaxis Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Lipid Tube Assembly Positive Regulation Of Inflammatory Response
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