SNX9 and PAK2

Number of citations of the paper that reports this interaction (PubMedID 16374509)
24

Data Source:
HPRD (in vitro)

		SNX9	PAK2
Description		sorting nexin 9	p21 (RAC1) activated kinase 2
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cuticular Plate Cell Projection Extracellular Exosome Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Nuclear Speck Secretory Granule Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Lipid Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation Regulation Of Synaptic Vesicle Endocytosis	Stimulatory C-type Lectin Receptor Signaling Pathway Cardiac Muscle Hypertrophy Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Starvation Cell Migration Adherens Junction Assembly Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Maturation Dendritic Spine Development Bicellular Tight Junction Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Execution Phase Of Apoptosis Regulation Of Actin Filament Organization Protein Localization To Cell-cell Junction Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494)	Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil count ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 27863252 32888494) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 27863252 32888494)
Interacting Genes		25 interacting genes: ADAM15 ADAM9 AP1G1 CEBPA CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MECOM MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 CEBPA DOCK2 DSCR9 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 OGT PACSIN3 PPM1A RAC1 RAF1 RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		51429	5062
HPRD ID		12072	05428
Ensembl ID		ENSG00000130340	ENSG00000180370
Uniprot IDs		Q9Y5X1	A8K5M4 Q13177
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE 7OJ9	3PCS
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Plasma Membrane Clathrin-coated Pit Vesicle Budding From Membrane Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Endocytosis Immune System Process Clathrin-coated Vesicle Phosphatidylinositol 3-kinase Complex, Class IB Import Into Cell Intracellular Signaling Cassette Kinase Activity Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Focal Adhesion Regulation Of Hematopoietic Progenitor Cell Differentiation Cytosol Regulation Of Immune System Process Phosphatidylinositol 3-kinase Complex Regulation Of Pro-B Cell Differentiation Regulation Of Cellular Component Organization Extracellular Exosome Phosphatidylinositol 3-kinase Complex, Class IA Cytoplasm Actin Filament-based Movement Epidermal Growth Factor Receptor Signaling Pathway Transferrin Transport Receptor-mediated Endocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphoid Progenitor Cell Differentiation Protein Serine Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Receptor Internalization Cellular Response To Type II Interferon Vesicle-mediated Transport Regulation Of ERBB Signaling Pathway Regulation Of Protein Metabolic Process Protein Polymerization Eyelid Development In Camera-type Eye ERBB Signaling Pathway Insulin Receptor Signaling Pathway Apoptotic Process Regulation Of Macromolecule Metabolic Process	Regulation Of Cellular Component Organization Cytosol Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cytoplasm Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Focal Adhesion Protein Phosphorylation Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Organelle Organization Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Fc Receptor Signaling Pathway Phosphorylation Positive Regulation Of Cytoskeleton Organization Signal Transduction Anchoring Junction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Organelle Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Immune Response-activating Signaling Pathway Actin Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Endocytosis Regulation Of Cell Activation Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Supramolecular Fiber Organization Actin Filament-based Process Protein Kinase Activity Lamellipodium
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?