SNX9 and PAK2

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vitro)

		SNX9	PAK2
Gene Name		sorting nexin 9	p21 protein (Cdc42/Rac)-activated kinase 2
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Protein Homodimerization Activity Arp2/3 Complex Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Mitotic Nuclear Division Vesicle Organization Endosomal Transport Positive Regulation Of Protein Oligomerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Tubulation	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System
Drugs
Diseases
GWAS			Total ventricular volume ( 21116278)
Protein-Protein Interactions		15 interactors: ADAM15 ADAM9 CLTC DNM1 DNM2 FASLG ITCH KHDRBS1 MPHOSPH6 MPP6 PAK2 SOS1 SOS2 TNK2 WASL	51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		51429	5062
HPRD ID		12072	05428
Ensembl ID		ENSG00000130340	ENSG00000180370
Uniprot IDs		Q9Y5X1	A8K5M4 Q13177
PDB IDs		2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE	3PCS
Enriched GO Terms of Interacting Partners?		Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Internalization Cell Morphogenesis Involved In Differentiation Axon Guidance Signal Transduction Cell Development Response To External Stimulus Locomotion Innate Immune Response Immune Response Neuron Projection Development Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Axonogenesis Neuron Development Receptor Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Cell Death Regulation Of Catalytic Activity Endocytosis Anatomical Structure Morphogenesis Neuron Differentiation Cellular Response To Stimulus Cell Projection Organization Developmental Process Positive Regulation Of Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Defense Response Nitric Oxide Metabolic Process Regulation Of Apoptotic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death
Tagcloud ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?