PDE4B and MID1

Number of citations of the paper that reports this interaction (PubMedID 34039624)
44

Data Source:
BioGRID (unspecified method)

		PDE4B	MID1
Description		phosphodiesterase 4B	midline 1
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Membrane Z Disc Dendritic Spine Excitatory Synapse Cell Periphery	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Gamma-tubulin Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction Neutrophil Chemotaxis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction
Pathways			Interferon gamma signaling
Drugs		Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases			Opitz-GBBB syndrome
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body size at age 10 ( 32376654) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)
Interacting Genes		55 interacting genes: ACTN4 ANXA6 ARCN1 C11orf98 CALR CAPZA2 CDK11B CFL2 ENO1 FLNA FUS G3BP2 GSN H1-4 HBB HSPD1 IFRD1 IMMT KRT18 KRT6B LCP1 LYAR MAGEA11 MID1 MPRIP MSH2 MYH14 MYO1E MYO5A NONO OAT P4HB PDIA6 PKM PLOD1 PPIA PRKACA RCBTB2 RCN3 RIC8A RPL24 RPL35 RPL5 RPN2 RPS20 RPS4X RPS8 RPSA SMURF2 SND1 SSR3 TMEM41B TPM4 YWHAB YWHAQ	46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618
Entrez ID		5142	4281
HPRD ID		02528	02047
Ensembl ID		ENSG00000184588	ENSG00000101871
Uniprot IDs		Q07343 Q59GM8 X5DNX5 X5DR82	A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344
PDB IDs		1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ 8OEG	2DQ5 2FFW 2JUN 5IM8 7QRY
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Focal Adhesion Actin Filament Binding Actin Binding Cytosolic Ribosome Cytoplasmic Translation Ribosome Cytoplasm Actin Cytoskeleton Structural Constituent Of Ribosome Melanosome Actin Filament-based Process Cytosolic Small Ribosomal Subunit Podosome Cytosol Actin Cytoskeleton Organization Actin Filament Organization Supramolecular Fiber Organization Ribonucleoprotein Complex Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Filament-based Movement Protein Folding Cadherin Binding Small Ribosomal Subunit Cortical Cytoskeleton Integrin Binding Translation Vesicle Transport Along Actin Filament Stress Fiber Actin Filament Microfilament Motor Activity Regulation Of Protein Depolymerization Organelle Organization GTPase Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Membrane Negative Regulation Of Actin Filament Polymerization Platelet Aggregation Myosin Complex Endoplasmic Reticulum Chaperone Complex Protein Metabolic Process Regulation Of Actin Filament Depolymerization Renal System Process Cytoskeletal Motor Activity Protein Folding In Endoplasmic Reticulum Actin Filament Depolymerization	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex
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