PDE4B and H1-4

Number of citations of the paper that reports this interaction (PubMedID 34039624)
44

Data Source:
BioGRID (unspecified method)

		PDE4B	H1-4
Description		phosphodiesterase 4B	H1.4 linker histone, cluster member
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Membrane Z Disc Dendritic Spine Excitatory Synapse Cell Periphery	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Chromosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Gamma-tubulin Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction Neutrophil Chemotaxis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil	Copper
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body size at age 10 ( 32376654) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)
Interacting Genes		55 interacting genes: ACTN4 ANXA6 ARCN1 C11orf98 CALR CAPZA2 CDK11B CFL2 ENO1 FLNA FUS G3BP2 GSN H1-4 HBB HSPD1 IFRD1 IMMT KRT18 KRT6B LCP1 LYAR MAGEA11 MID1 MPRIP MSH2 MYH14 MYO1E MYO5A NONO OAT P4HB PDIA6 PKM PLOD1 PPIA PRKACA RCBTB2 RCN3 RIC8A RPL24 RPL35 RPL5 RPN2 RPS20 RPS4X RPS8 RPSA SMURF2 SND1 SSR3 TMEM41B TPM4 YWHAB YWHAQ	10 interacting genes: CBX1 CBX3 CBX5 FOXP1 IL7R IRAK4 OGT PDE4B PRKCA RBFOX2
Entrez ID		5142	3008
HPRD ID		02528	07513
Ensembl ID		ENSG00000184588	ENSG00000168298
Uniprot IDs		Q07343 Q59GM8 X5DNX5 X5DR82	A3R0T8 P10412
PDB IDs		1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ 8OEG	3TZD 5JJZ 6H8P 7K5Y 7K63 7PET 7PEU 7PEX 7PEZ 7PF0 7PF2 7PF3 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFT 7PFU 7PFV 7PFW 7PFX 8H1T 8VG2 9DDE
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Focal Adhesion Actin Filament Binding Actin Binding Cytosolic Ribosome Cytoplasmic Translation Ribosome Cytoplasm Actin Cytoskeleton Structural Constituent Of Ribosome Melanosome Actin Filament-based Process Cytosolic Small Ribosomal Subunit Podosome Cytosol Actin Cytoskeleton Organization Actin Filament Organization Supramolecular Fiber Organization Ribonucleoprotein Complex Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Filament-based Movement Protein Folding Cadherin Binding Small Ribosomal Subunit Cortical Cytoskeleton Integrin Binding Translation Vesicle Transport Along Actin Filament Stress Fiber Actin Filament Microfilament Motor Activity Regulation Of Protein Depolymerization Organelle Organization GTPase Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Membrane Negative Regulation Of Actin Filament Polymerization Platelet Aggregation Myosin Complex Endoplasmic Reticulum Chaperone Complex Protein Metabolic Process Regulation Of Actin Filament Depolymerization Renal System Process Cytoskeletal Motor Activity Protein Folding In Endoplasmic Reticulum Actin Filament Depolymerization	Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Negative Regulation Of Gene Expression Positive Regulation Of Smooth Muscle Cell Proliferation Chromocenter Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Histone Methyltransferase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Gene Expression, Epigenetic Chromosome, Centromeric Region Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Negative Regulation Of Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Regulation Of Muscle System Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Metabolic Process Regulation Of Lymphocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neutrophil Migration Response To Lipid Regulation Of Cardiac Muscle Hypertrophy DNA Damage Response Regulation Of RNA Metabolic Process Leukocyte Homeostasis Regulation Of Primary Metabolic Process Regulation Of Immune System Process Interleukin-7 Receptor Activity
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