PDE4B and CALR

Number of citations of the paper that reports this interaction (PubMedID 34039624)
44

Data Source:
BioGRID (unspecified method)

		PDE4B	CALR
Description		phosphodiesterase 4B	calreticulin
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Membrane Z Disc Dendritic Spine Excitatory Synapse Cell Periphery	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion External Side Of Plasma Membrane Cell Surface Endomembrane System Membrane Sarcoplasmic Reticulum Phagocytic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Cytolytic Granule Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Extracellular Exosome Endocytic Vesicle Lumen Lumenal Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Gamma-tubulin Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Metal Ion Binding Nuclear Androgen Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Molecular Sequestering Activity
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction Neutrophil Chemotaxis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of DNA-templated Transcription Protein Folding Protein Export From Nucleus Intracellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ERAD Pathway Regulation Of Meiotic Nuclear Division Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Protein Maturation Cardiac Muscle Cell Differentiation Cellular Response To Electrical Stimulus Cellular Response To Lithium Ion Cellular Senescence Cellular Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Peptide Response To Glycoside Response To Biphenyl Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil	Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body size at age 10 ( 32376654) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)
Interacting Genes		55 interacting genes: ACTN4 ANXA6 ARCN1 C11orf98 CALR CAPZA2 CDK11B CFL2 ENO1 FLNA FUS G3BP2 GSN H1-4 HBB HSPD1 IFRD1 IMMT KRT18 KRT6B LCP1 LYAR MAGEA11 MID1 MPRIP MSH2 MYH14 MYO1E MYO5A NONO OAT P4HB PDIA6 PKM PLOD1 PPIA PRKACA RCBTB2 RCN3 RIC8A RPL24 RPL35 RPL5 RPN2 RPS20 RPS4X RPS8 RPSA SMURF2 SND1 SSR3 TMEM41B TPM4 YWHAB YWHAQ	50 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDE4B PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TSHR UBE3A UPF2 VWF
Entrez ID		5142	811
HPRD ID		02528	00169
Ensembl ID		ENSG00000184588	ENSG00000179218
Uniprot IDs		Q07343 Q59GM8 X5DNX5 X5DR82	P27797 V9HW88
PDB IDs		1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ 8OEG	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Focal Adhesion Actin Filament Binding Actin Binding Cytosolic Ribosome Cytoplasmic Translation Ribosome Cytoplasm Actin Cytoskeleton Structural Constituent Of Ribosome Melanosome Actin Filament-based Process Cytosolic Small Ribosomal Subunit Podosome Cytosol Actin Cytoskeleton Organization Actin Filament Organization Supramolecular Fiber Organization Ribonucleoprotein Complex Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Filament-based Movement Protein Folding Cadherin Binding Small Ribosomal Subunit Cortical Cytoskeleton Integrin Binding Translation Vesicle Transport Along Actin Filament Stress Fiber Actin Filament Microfilament Motor Activity Regulation Of Protein Depolymerization Organelle Organization GTPase Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Membrane Negative Regulation Of Actin Filament Polymerization Platelet Aggregation Myosin Complex Endoplasmic Reticulum Chaperone Complex Protein Metabolic Process Regulation Of Actin Filament Depolymerization Renal System Process Cytoskeletal Motor Activity Protein Folding In Endoplasmic Reticulum Actin Filament Depolymerization	Cell Surface Integrin Binding External Side Of Plasma Membrane Platelet Alpha Granule Cell Adhesion Endoplasmic Reticulum Lumen Antigen Processing And Presentation Of Endogenous Antigen Cell-cell Adhesion Platelet Alpha Granule Lumen Extracellular Space Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune System Process Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Regulation Of Extrinsic Apoptotic Signaling Pathway Extracellular Exosome Antibacterial Humoral Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Immune System Process MHC Class I Peptide Loading Complex Positive Regulation Of Cell Killing MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Positive Regulation Of Gene Expression Response To Hormone Reproductive Behavior Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Tapasin-ERp57 Complex Positive Regulation Of Endocytosis Regulation Of T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Platelet Aggregation Negative Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor Production Blood Coagulation Cellular Response To Amyloid-beta Apolipoprotein Binding Coagulation Signaling Receptor Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Tumor Necrosis Factor Production Heparan Sulfate Proteoglycan Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?