PDE4B

Gene Name		phosphodiesterase 4B, cAMP-specific
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Voltage-gated Calcium Channel Complex Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CAMP Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Cellular Response To Drug T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Relaxation Of Cardiac Muscle
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs		Adenosine monophosphate Caffeine Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Iloprost Papaverine Theobromine Amrinone (R)-Mesopram Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5\'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634)
Protein-protein Interactions		4 interactors: DISC1 MAGEA11 PRKACA RCBTB2
Entrez ID		5142
HPRD ID		02528
Ensembl ID		ENSG00000184588
Uniprot IDs		Q07343 Q59GM8
PDB IDs		1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 4KP6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Catabolic Process Cellular Metal Ion Homeostasis Positive Regulation Of Ran GTPase Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Chemical Homeostasis Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Signal Transduction Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Mitochondrial Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Synapse Maturation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Homeostasis Triglyceride Catabolic Process Negative Regulation Of Adenylate Cyclase Activity TOR Signaling Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Metabolic Process
Tagcloud ?		acrdy2 acrodysostosis allosteric augmenting closing cognition consolidation cr3 dampening discover elucidation intellectual mechanistically mim modulators monophosphate nams neuroinflammation nonamyloid pde4a pde4d phosphodiesterase positron strict ucr2 ultra underexploited underscored