PDE4B and HBB

Number of citations of the paper that reports this interaction (PubMedID 34039624)
44

Data Source:
BioGRID (unspecified method)

		PDE4B	HBB
Description		phosphodiesterase 4B	hemoglobin subunit beta
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Membrane Z Disc Dendritic Spine Excitatory Synapse Cell Periphery	Extracellular Region Extracellular Space Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Gamma-tubulin Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Peroxidase Activity Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Binding Haptoglobin Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction Neutrophil Chemotaxis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Inflammatory Response Regulation Of Blood Pressure Carbon Dioxide Transport Oxygen Transport Nitric Oxide Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Erythrocyte Development Renal Absorption Platelet Aggregation Blood Vessel Diameter Maintenance Cellular Oxidant Detoxification
Pathways			Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Neutrophil degranulation Chaperone Mediated Autophagy Late endosomal microautophagy Cytoprotection by HMOX1 Heme signaling Factors involved in megakaryocyte development and platelet production Heme assimilation
Drugs		Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil	Iron Dextran Zinc 4-Carboxycinnamic Acid Pentaerythritol tetranitrate 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine Sebacic acid 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2,6-dicarboxynaphthalene Efaproxiral Trimesic acid Nitrous acid Copper Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Sickle cell anemia (SCA) Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body size at age 10 ( 32376654) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)	Blood cell traits (multivariate analysis) ( 31080455) Estimated glomerular filtration rate ( 33783510) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) F-cell distribution ( 17767159) Fetal hemoglobin levels ( 18245381) Glycated hemoglobin levels ( 34059833 31213470) HbA2 levels ( 23043469) Hematocrit ( 28453575 31869403) Hematology traits ( 23263863) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553 31869403) hemolysis of donated blood (osmotic) ( 34014839) Inflammatory biomarkers ( 22291609) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Low density lipoprotein cholesterol levels ( 33339817) Malaria ( 19465909 23717212 31844061 22895189) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 23263863 28453575) Mean corpuscular volume ( 32888494 28453575) Red cell distribution width ( 31080455) Severe malaria ( 29381699) Total cholesterol levels ( 33339817) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31511532 32600054 27650483)
Interacting Genes		55 interacting genes: ACTN4 ANXA6 ARCN1 C11orf98 CALR CAPZA2 CDK11B CFL2 ENO1 FLNA FUS G3BP2 GSN H1-4 HBB HSPD1 IFRD1 IMMT KRT18 KRT6B LCP1 LYAR MAGEA11 MID1 MPRIP MSH2 MYH14 MYO1E MYO5A NONO OAT P4HB PDIA6 PKM PLOD1 PPIA PRKACA RCBTB2 RCN3 RIC8A RPL24 RPL35 RPL5 RPN2 RPS20 RPS4X RPS8 RPSA SMURF2 SND1 SSR3 TMEM41B TPM4 YWHAB YWHAQ	13 interacting genes: HBA1 HBA2 HBG2 HBM HBQ1 HBZ HP LINC02582 PABPC1 PDE4B SELENOT UCHL5 UPF3B
Entrez ID		5142	3043
HPRD ID		02528	00786
Ensembl ID		ENSG00000184588	ENSG00000244734
Uniprot IDs		Q07343 Q59GM8 X5DNX5 X5DR82	D9YZU5 P68871
PDB IDs		1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ 8OEG	1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S65 3S66 3SZK 3W4U 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 4ROL 4ROM 4WJG 4X0L 4XS0 5E29 5E6E 5E83 5EE4 5HU6 5HY8 5JDO 5KDQ 5KSI 5KSJ 5NI1 5SW7 5U3I 5UCU 5UFJ 5URC 5VMM 5WOG 5WOH 5X2R 5X2S 5X2T 5X2U 6BB5 6BNR 6BWP 6BWU 6DI4 6FQF 6HAL 6HBW 6HK2 6KA9 6KAE 6KAH 6KAI 6KAO 6KAP 6KAQ 6KAR 6KAS 6KAT 6KAU 6KAV 6KYE 6L5V 6L5W 6L5X 6L5Y 6LCW 6LCX 6NBC 6NBD 6NQ5 6TB2 6XD9 6XDT 6XE7 7AET 7AEU 7AEV 7CUE 7DY3 7DY4 7JJQ 7JXZ 7JY0 7JY1 7JY3 7K4M 7PCF 7PCH 7PCQ 7UD7 7UD8 7UF6 7UF7 7UVB 7VDE 7XGY 8DOV 8EGI 8FDK 8FDL 8FDM 8FDN 8VYL 8WJ0 8WJ1 8WJ2 8WXZ 8XMP 8XMQ 8XMW 9AV9 9AYZ 9BCJ 9FHB 9FMU 9FNO
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Focal Adhesion Actin Filament Binding Actin Binding Cytosolic Ribosome Cytoplasmic Translation Ribosome Cytoplasm Actin Cytoskeleton Structural Constituent Of Ribosome Melanosome Actin Filament-based Process Cytosolic Small Ribosomal Subunit Podosome Cytosol Actin Cytoskeleton Organization Actin Filament Organization Supramolecular Fiber Organization Ribonucleoprotein Complex Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Filament-based Movement Protein Folding Cadherin Binding Small Ribosomal Subunit Cortical Cytoskeleton Integrin Binding Translation Vesicle Transport Along Actin Filament Stress Fiber Actin Filament Microfilament Motor Activity Regulation Of Protein Depolymerization Organelle Organization GTPase Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Membrane Negative Regulation Of Actin Filament Polymerization Platelet Aggregation Myosin Complex Endoplasmic Reticulum Chaperone Complex Protein Metabolic Process Regulation Of Actin Filament Depolymerization Renal System Process Cytoskeletal Motor Activity Protein Folding In Endoplasmic Reticulum Actin Filament Depolymerization	Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Carbon Dioxide Transport Hemopoiesis One-carbon Compound Transport Endocytic Vesicle Lumen Cellular Oxidant Detoxification Cellular Detoxification Iron Ion Binding Haptoglobin Binding Blood Microparticle Nitric Oxide Transport Cell Development Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Response To Reactive Oxygen Species Peroxidase Activity Hydrogen Peroxide Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay G Protein-coupled Receptor Binding Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Relaxation Of Cardiac Muscle Catabolic Process Nucleobase-containing Compound Catabolic Process Response To Oxidative Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of Catabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Regulation Of Translation Developmental Process Hemoglobin Alpha Binding Hemoglobin Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway MCRD-mediated MRNA Stability Complex MRNA Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Relaxation Of Muscle Positive Regulation Of MRNA Metabolic Process Thioredoxin-disulfide Reductase (NADPH) Activity
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