PDE4B and G3BP2

Number of citations of the paper that reports this interaction (PubMedID 34039624)
44

Data Source:
BioGRID (unspecified method)

		PDE4B	G3BP2
Description		phosphodiesterase 4B	G3BP stress granule assembly factor 2
Image
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Membrane Z Disc Dendritic Spine Excitatory Synapse Cell Periphery	Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Gamma-tubulin Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction Neutrophil Chemotaxis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Immune System Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly
Pathways			SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body size at age 10 ( 32376654) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)	HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Interacting Genes		55 interacting genes: ACTN4 ANXA6 ARCN1 C11orf98 CALR CAPZA2 CDK11B CFL2 ENO1 FLNA FUS G3BP2 GSN H1-4 HBB HSPD1 IFRD1 IMMT KRT18 KRT6B LCP1 LYAR MAGEA11 MID1 MPRIP MSH2 MYH14 MYO1E MYO5A NONO OAT P4HB PDIA6 PKM PLOD1 PPIA PRKACA RCBTB2 RCN3 RIC8A RPL24 RPL35 RPL5 RPN2 RPS20 RPS4X RPS8 RPSA SMURF2 SND1 SSR3 TMEM41B TPM4 YWHAB YWHAQ	68 interacting genes: ANXA1 CEBPA DANCR MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA OGT PDE4B PIN1 PRMT5 RIOK1 TRIM25 USP10 ZNF618
Entrez ID		5142	9908
HPRD ID		02528	06570
Ensembl ID		ENSG00000184588	ENSG00000138757
Uniprot IDs		Q07343 Q59GM8 X5DNX5 X5DR82	A0A7I2V3P9 A0A7I2V647 Q9UN86
PDB IDs		1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ 8OEG	5DRV
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Focal Adhesion Actin Filament Binding Actin Binding Cytosolic Ribosome Cytoplasmic Translation Ribosome Cytoplasm Actin Cytoskeleton Structural Constituent Of Ribosome Melanosome Actin Filament-based Process Cytosolic Small Ribosomal Subunit Podosome Cytosol Actin Cytoskeleton Organization Actin Filament Organization Supramolecular Fiber Organization Ribonucleoprotein Complex Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Filament-based Movement Protein Folding Cadherin Binding Small Ribosomal Subunit Cortical Cytoskeleton Integrin Binding Translation Vesicle Transport Along Actin Filament Stress Fiber Actin Filament Microfilament Motor Activity Regulation Of Protein Depolymerization Organelle Organization GTPase Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Membrane Negative Regulation Of Actin Filament Polymerization Platelet Aggregation Myosin Complex Endoplasmic Reticulum Chaperone Complex Protein Metabolic Process Regulation Of Actin Filament Depolymerization Renal System Process Cytoskeletal Motor Activity Protein Folding In Endoplasmic Reticulum Actin Filament Depolymerization	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Extracellular Space
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