HOOK1 and CDC5L

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		HOOK1	CDC5L
Gene Name		hook microtubule-tethering protein 1	cell division cycle 5-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Microtubule HOPS Complex FHF Complex	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding
	Biological Process	Endosome Organization Lysosome Organization Multicellular Organismal Development Spermatid Development Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)
Protein-Protein Interactions		18 interactors: AKTIP ANK3 CDC5L CDK4 FAM160A2 HOOK2 HOOK3 LMO2 SYCE1 TBC1D7 TFIP11 USP2 VPS16 VPS18 VPS39 VPS41 ZNF250 ZNF785	69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1
Entrez ID		51361	988
HPRD ID		07428	04184
Ensembl ID		ENSG00000134709	ENSG00000096401
Uniprot IDs		Q9UJC3	Q99459
PDB IDs			2DIM 2DIN
Enriched GO Terms of Interacting Partners?		Endosome Organization Vacuole Organization Lysosome Organization Early Endosome To Late Endosome Transport Vacuolar Transport Endosome To Lysosome Transport Regulation Of SNARE Complex Assembly Lysosomal Transport Protein Transport Establishment Of Protein Localization Endosomal Transport Intracellular Transport Endomembrane System Organization Regulation Of Vesicle Fusion Protein Localization Vesicle-mediated Transport Establishment Of Localization In Cell Cytoplasmic Transport Cellular Localization Organelle Organization Cellular Protein Localization Intracellular Protein Transport Viral Entry Into Host Cell Entry Into Host Cell Maintenance Of Protein Location In Plasma Membrane Regulation Of Vacuole Fusion, Non-autophagic Spliceosomal Complex Disassembly Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vacuole Fusion, Non-autophagic Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Regulation Of Protein Complex Assembly Negative Regulation Of Cilium Assembly Cell Cycle Regulation Of Vesicle-mediated Transport Interaction With Host Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Membrane Depolarization During Action Potential Regulation Of Organelle Organization Maintenance Of Protein Location In Cell Transport Maintenance Of Protein Location Regulation Of Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Regulation Of Delayed Rectifier Potassium Channel Activity Cell Cycle Process Circadian Rhythm	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport
Tagcloud ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 diagnostics dnajc12 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Difference) ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 diagnostics dnajc12 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Intersection) ?