HOOK1 and ANK3

Number of citations of the paper that reports this interaction (PubMedID 15823567)
0

Data Source:
HPRD (two hybrid, in vitro)

		HOOK1	ANK3
Description		hook microtubule tethering protein 1	ankyrin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways			Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	22 interacting genes: FADD FAS GABARAP HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 NAB2 NEDD4 PIK3R1 PLEC RIPK4 RNF10 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4 SRPK2 YAP1
Entrez ID		51361	288
HPRD ID		07428	02715
Ensembl ID		ENSG00000134709	ENSG00000151150
Uniprot IDs		Q9UJC3	Q12955 Q8NAK2
PDB IDs			4O6X
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport
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