HOOK1 and RPS7

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		HOOK1	RPS7
Description		hook microtubule tethering protein 1	ribosomal protein S7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Ribosome Cytoskeleton Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Protein-containing Complex Synapse Ribonucleoprotein Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	Neural Tube Closure Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Neural Crest Cell Differentiation Ribosomal Small Subunit Biogenesis Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	12 interacting genes: CDKN2A DUX4 EIF4ENIF1 HOOK1 IPO5 IPO7 NEK6 OGT RPS4X TNPO1 UPF2 ZBTB14
Entrez ID		51361	6201
HPRD ID		07428	04712
Ensembl ID		ENSG00000134709	ENSG00000171863
Uniprot IDs		Q9UJC3	P62081
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Nucleolus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Cycle Cytosol Intracellular Protein Localization Nuclear Import Signal Receptor Activity Intracellular Transport Establishment Of Protein Localization To Organelle Nuclear Localization Sequence Binding Cytoplasm Regulation Of Protein Localization To Nucleus Nucleoplasm RNA Binding Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport Ligase Inhibitor Activity Nucleus Regulation Of Cell Cycle Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Lipid Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Small GTPase Binding Negative Regulation Of Protein Ubiquitination Positive Regulation Of Gene Expression Autophagy Of Mitochondrion Stress-induced Mitochondrial Fusion Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Nuclear Pore Negative Regulation Of Post-translational Protein Modification Translation Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Catabolic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus
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