CDC5L and TRIO

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CDC5L	TRIO
Gene Name		cell division cycle 5-like	trio Rho guanine nucleotide exchange factor
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE DCC mediated attractive signaling p75 NTR receptor-mediated signalling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Netrin-1 signaling
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)	Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	11 interactors: BLMH CDC5L DISC1 EXOC1 FLNA ITSN2 MAPRE1 PTK2 PTPRF RAC1 RHOA
Entrez ID		988	7204
HPRD ID		04184	03537
Ensembl ID		ENSG00000096401	ENSG00000038382
Uniprot IDs		Q99459	O75962
PDB IDs		2DIM 2DIN	1NTY 2NZ8
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	Platelet Activation Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Migration Cell Motility Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cytoskeleton Organization Regulation Of Body Fluid Levels Wound Healing Locomotion Organelle Organization Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Cell Activation Positive Regulation Of Stress Fiber Assembly Response To Wounding Regulation Of Focal Adhesion Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Negative Regulation Of Axonogenesis Microtubule-based Process Cellular Localization Movement Of Cell Or Subcellular Component Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Mitotic Nuclear Division Positive Regulation Of Intracellular Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Stress Fiber Assembly Cell Projection Morphogenesis Regulation Of Rho Protein Signal Transduction Regulation Of Cell Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Projection Development Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Intersection) ?