HOOK1 and FHIP1B

Number of citations of the paper that reports this interaction (PubMedID 34882091)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		HOOK1	FHIP1B
Description		hook microtubule tethering protein 1	FHF complex subunit HOOK interacting protein 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	FHF Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	9 interacting genes: AGTRAP AKTIP HOOK1 HOOK2 RAB5B RABAC1 REEP6 RTN1 RTN3
Entrez ID		51361	84067
HPRD ID		07428	08002
Ensembl ID		ENSG00000134709	ENSG00000051009
Uniprot IDs		Q9UJC3	Q8N612
PDB IDs			8QAT
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm HOPS Complex Endosome Organization Early Endosome To Late Endosome Transport Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Formation Lysosome Organization Endosome To Lysosome Transport Endosomal Transport Endoplasmic Reticulum Tubular Network Membrane Organization Vesicle Organization Endoplasmic Reticulum Membrane Organization Lysosomal Transport Organelle Organization Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Amyloid-beta Formation Vacuolar Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Vacuole Organization Dynein Light Intermediate Chain Binding Vesicle-mediated Transport Regulation Of Amyloid-beta Formation Golgi Apparatus Regulation Of Amyloid Precursor Protein Catabolic Process Cytoplasmic Microtubule Organization Regulation Of Amide Metabolic Process Endoplasmic Reticulum Membrane Protein Transport Intracellular Transport Angiotensin Type II Receptor Activity Establishment Of Protein Localization Golgi Membrane Manchette Assembly Cytoskeleton-dependent Intracellular Transport Cellular Localization Plasma Membrane To Endosome Transport Endoplasmic Reticulum Positive Regulation Of Protein Binding Establishment Of Localization In Cell Brain Development Postsynaptic Density Microtubule Binding Cytoplasmic Vesicle Intracellular Protein Localization Identical Protein Binding Proline-rich Region Binding Ubiquitin-like Protein Transferase Activity GTP-dependent Protein Binding Angiotensin-activated Signaling Pathway
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