CDC5L and EXOC7

Number of citations of the paper that reports this interaction (PubMedID 20467437)
28

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDC5L	EXOC7
Description		cell division cycle 5 like	exocyst complex component 7
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Membrane Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Exocyst Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Membrane Midbody Growth Cone Membrane Centriolar Satellite Flemming Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding WD40-repeat Domain Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling MRNA Splicing, Via Spliceosome DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing DNA Damage Response RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Entry Of Bacterium Into Host Cell
Pathways		mRNA Splicing - Major Pathway	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Chin dimples ( 27182965) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) FEV1 ( 30804560) Height ( 28552196) Ischemic stroke ( 26089329) Lung function (FVC) ( 30804560) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Nose morphology ( 29921221) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis ( 22763110) Osteoarthritis of the hand ( 28855172) Serum alkaline phosphatase levels ( 33547301) Stroke (ischemic) ( 22941190) Trunk fat mass adjusted for trunk lean mass ( 32239398)	Body size at age 10 ( 32376654)
Interacting Genes		92 interacting genes: AKAP6 AKAP9 ANXA1 BICRAL CALM1 CCDC136 CDC42 CDK2 CDKN1A CDKN2A CDT1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HNRNPM HOOK1 KALRN KANK2 KANSL1 KIF3C KIF5B KRT18 LDOC1 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MIR106B MIR107 MIR143 MIR200B MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR429 MIRLET7A2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MTUS2 MYT1L OGT ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF3 RNF10 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 SYNPO TP53BP2 TRAF3IP1 TRAK1 TRIO TTF2 TXLNA USHBP1 USP7 VPS52 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	40 interacting genes: AKTIP ARFGEF2 ARPC1A BBS1 BBS2 BBS4 CCDC85B CCHCR1 CDC5L CT55 DISC1 DLG3 EXOC2 EXOC4 FBXO28 GRIN2B HGS IFT20 KDM1A KIFC3 KXD1 MSGN1 NRIP1 OLIG2 PKNOX1 PLEKHF2 PRPF19 RALA RALY RHOQ RTN4IP1 SAPCD2 SMARCE1 SNAPIN SSC5D TRAF4 TRIM54 USHBP1 YAE1 ZC3H14
Entrez ID		988	23265
HPRD ID		04184	16292
Ensembl ID		ENSG00000096401	ENSG00000182473
Uniprot IDs		Q99459	B4DJ07 B5MCY9 Q9UPT5
PDB IDs		2DIM 2DIN 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABH 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex DNA Replication Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression DNA Replication Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Origin Recognition Complex Regulation Of DNA Replication Positive Regulation Of Tissue Remodeling Chromosome, Telomeric Region Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Translation Extracellular Vesicle Nuclear Origin Of Replication Recognition Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoskeleton CMG Complex MCM Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Double-strand Break Repair Via Break-induced Replication Negative Regulation Of Transmembrane Transport Regulation Of Cell Cycle Glutamatergic Synapse Regulation Of Connective Tissue Replacement Molecular Adaptor Activity Microtubule Binding Negative Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly	BBSome Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Vesicle-mediated Transport Localization Within Membrane Cytoskeleton Intracellular Protein Localization Cellular Localization Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Striatum Development Regulation Of Cilium Beat Frequency Non-motile Cilium Assembly Microtubule-based Process Brain Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Endosome Organization Cerebral Cortex Development Flemming Body Protein Binding Regulation Of Cilium Movement Organelle Localization Exocytosis Centrosome Photoreceptor Cell Maintenance Motile Cilium Regulation Of Lysosome Size BORC Complex Membrane Fission Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm Vesicle Tethering Involved In Exocytosis Lysosomal Transport Leptin-mediated Signaling Pathway Regulation Of Microtubule-based Movement Ciliary Membrane Regulation Of Endosome Size Endosome To Lysosome Transport Cilium Assembly Negative Regulation Of Appetite Establishment Of Organelle Localization Protein Localization To Cilium DNA Replication Factor A Complex Cytoplasmic Side Of Lysosomal Membrane Golgi Vesicle Transport
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