HOOK1 and HOOK3

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		HOOK1	HOOK3
Description		hook microtubule tethering protein 1	hook microtubule tethering protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex	Pericentriolar Material Cytoplasm Golgi Apparatus Cis-Golgi Network Centrosome Cytoskeleton Microtubule HOPS Complex Centriolar Satellite FHF Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Zinc levels ( 26025379)
Interacting Genes		46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	11 interacting genes: AKTIP CTIF EIF4ENIF1 HOOK1 HOOK2 KRT13 MAPT MEOX2 PNMA5 VPS16 VPS41
Entrez ID		51361	84376
HPRD ID		07428	09699
Ensembl ID		ENSG00000134709	ENSG00000168172
Uniprot IDs		Q9UJC3	Q86VS8
PDB IDs			5J8E 6B9H 8QAT 9KNS 9KO8
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex	HOPS Complex Endosome To Lysosome Transport FHF Complex Lysosomal Transport Protein Localization To Perinuclear Region Of Cytoplasm Vacuolar Transport Early Endosome To Late Endosome Transport Vesicle Organization Vacuole Organization Intracellular Transport Cytoplasmic Microtubule Organization Lysosome Organization Microtubule Binding Endosome Organization Endosomal Transport Cellular Localization Establishment Of Localization In Cell Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Transport Organelle Organization Establishment Of Protein Localization Dynein Light Intermediate Chain Binding Supramolecular Fiber Organization Cytoskeleton-dependent Intracellular Transport Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Microtubule Cytoskeleton Intracellular Protein Localization Vesicle-mediated Transport Neurofibrillary Tangle Assembly Clathrin-coated Vesicle Lysosomal HOPS Complex Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vacuole Fusion, Non-autophagic Indoleamine 2,3-dioxygenase Activity Cytoplasmic Ribonucleoprotein Granule Microtubule Tryptophan 2,3-dioxygenase Activity Vesicle Fusion Actin Binding Organelle Membrane Fusion PML Body Vesicle Tethering Complex Regulation Of Translation Regulation Of Protein Metabolic Process Main Axon Negative Regulation Of Mitochondrial Fission
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