RPS7 and CDKN2A

Number of citations of the paper that reports this interaction (PubMedID 16582619)
0

Data Source:
HPRD (two hybrid)

		RPS7	CDKN2A
Description		ribosomal protein S7	cyclin dependent kinase inhibitor 2A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Ribosome Cytoskeleton Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Protein-containing Complex Synapse Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Body Protein-containing Complex Senescence-associated Heterochromatin Focus
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity	P53 Binding DNA Binding RNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SUMO Transferase Activity Protein Kinase Binding NF-kappaB Binding Ligase Inhibitor Activity Ubiquitin-protein Transferase Inhibitor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding Disordered Domain Specific Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Neural Tube Closure Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Neural Crest Cell Differentiation Ribosomal Small Subunit Biogenesis Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Autophagy Of Mitochondrion Negative Regulation Of Cell-matrix Adhesion RRNA Processing Apoptotic Process Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Epidermis Development RRNA Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Protein Sumoylation Keratinocyte Differentiation Negative Regulation Of Cell Growth Nuclear Body Organization Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Protein Localization To Nucleus Somatic Stem Cell Population Maintenance Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Keratinocyte Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Regulation Of Cell Cycle Mitochondrial Depolarization Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Hydrogen Peroxide Protein K63-linked Ubiquitination Cellular Senescence Replicative Senescence Oncogene-induced Cell Senescence Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin Protein Ligase Activity Amyloid Fibril Formation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of Protein Neddylation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Nuclear events mediated by NFE2L2
Drugs
Diseases		Diamond-Blackfan anemia (DBA)	Chronic myeloid leukemia (CML) Non-small cell lung cancer Malignant islet cell carcinoma Adult T-cell leukemia Esophageal cancer Glioma Pancreatic cancer Nasopharyngeal cancer Hepatocellular carcinoma Squamous cell carcinoma Penile cancer Oral cancer Malignant melanoma Burkitt lymphoma Gallbladder cancer Bladder cancer Laryngeal cancer Cholangiocarcinoma Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
GWAS		Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Serum alkaline phosphatase levels ( 33547301)	Abdominal aortic aneurysm ( 20622881) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 24403052) Basophil count ( 32888494) Breast cancer ( 23535729 29059683 20453838) Coronary artery calcification ( 23561647) Coronary artery disease ( 29263402 26708285 21239051) Coronary heart disease ( 21971053 21378990 17554300) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Eosinophil count ( 32888494) Esophageal squamous cell carcinoma ( 25129146) Fasting plasma glucose ( 25187374) Glioblastoma ( 28346443) Glioma ( 21531791 28346443 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 28212542 19578364 21983787) Monocyte count ( 27863252 32888494) Multiple myeloma ( 27363682) Myocardial infarction ( 17478679 26708285) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443) Non-small cell lung cancer ( 31326317) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Platelet count ( 27863252 22139419 32888494) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spleen volume ( 34128465) Type 2 diabetes ( 23209189 17463246 17463248 17463249 18372903 19401414 20581827 21573907 30718926 23945395 24509480 26818947 26961502 27189021 32499647 29358691 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		12 interacting genes: CDKN2A DUX4 EIF4ENIF1 HOOK1 IPO5 IPO7 NEK6 OGT RPS4X TNPO1 UPF2 ZBTB14	168 interacting genes: - ACLY ACTB ACTG1 ACTN4 AHNAK AKT1 ALDOB ANAPC15 ANGPTL4 ANKRA2 ANKRD12 AOPEP ARFIP2 ARNT ASPRV1 AZIN1 BAAT BCL2L1 BECN1 CARF CASC3 CCDC180 CCDC183 CCND2 CCNDBP1 CCNE1 CCNG1 CD44 CDC14B CDC42 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CENPA CRELD2 CTBP2 CTSV CYLC2 DEAF1 E2F1 E4F1 EEF2 EFHC2 EGR1 EPHA2 EPHA3 EXOC2 FGFR4 FN1 FRAT2 GALNT12 GAPDH GGA1 GGA3 GLIS1 GLIS2 GMNN GSPT1 H2BC26 HGF HIF1A HLA-DOB HNRNPA2B1 HNRNPC HNRNPU HRAS HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 ISOC2 KAT5 LATS2 MAF1 MAP2K1 MAP2K5 MAP3K5 MAPK10 MAPK14 MAPK3 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MDM4 MKRN1 MMRN1 MTR MYC MYL12A NAT2 NCL NMI NOP53 NPM1 NSD3 ORC4 PCNA PDCD6 PDGFRA PEX19 PPP1R9B PRKCA PSMC3 PTP4A3 RAF1 RASA1 RASSF1 RBM26 RIN2 RPL11 RPS7 RUVBL2 SEC61B SERTAD1 SFRP4 SGK1 SIVA1 SIX2 SLC4A1 SMARCA4 SNRPA SNRPB SOX3 SOX4 STK11 TBRG1 TDRD7 TEAD2 TERT TFDP1 TGFB1 TMEFF1 TMOD1 TP63 TPI1 TRIM28 TRIP12 TSC1 TUBA1A TUBA1C TUBB TUBB4B UBC UBE2A UBE4B UBL7 USP26 VAMP1 VHL WRN YY1 ZFP91 ZGRF1 ZNF227 ZNF410 ZNF420 ZNF687 ZUP1
Entrez ID		6201	1029
HPRD ID		04712	02542
Ensembl ID		ENSG00000171863	ENSG00000147889
Uniprot IDs		P62081	K7PML8 P42771 Q8N726
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1A5E 1BI7 1DC2 2A5E 7OZT
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Nucleolus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Cycle Cytosol Intracellular Protein Localization Nuclear Import Signal Receptor Activity Intracellular Transport Establishment Of Protein Localization To Organelle Nuclear Localization Sequence Binding Cytoplasm Regulation Of Protein Localization To Nucleus Nucleoplasm RNA Binding Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport Ligase Inhibitor Activity Nucleus Regulation Of Cell Cycle Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Lipid Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Small GTPase Binding Negative Regulation Of Protein Ubiquitination Positive Regulation Of Gene Expression Autophagy Of Mitochondrion Stress-induced Mitochondrial Fusion Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Nuclear Pore Negative Regulation Of Post-translational Protein Modification Translation Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Catabolic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus	Nucleus Nucleoplasm Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Cell Population Proliferation Response To Stress Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Metabolic Process Cytosol Regulation Of DNA Metabolic Process Regulation Of Protein Metabolic Process Response To Radiation Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Replication Initiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle DNA Metabolic Process Positive Regulation Of Biosynthetic Process Nucleotide Binding Regulation Of Cellular Component Organization Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Cellular Senescence ATP Binding Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Catalytic Activity Cellular Response To Radiation Positive Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Positive Regulation Of Fibroblast Proliferation Nucleobase-containing Compound Metabolic Process
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