TNFRSF12A and TRAF5

Number of citations of the paper that reports this interaction (PMID 12529173)
38

Data Source:
HPRD (two hybrid, in vitro)

		TNFRSF12A	TRAF5
Gene Name		tumor necrosis factor receptor superfamily, member 12A	TNF receptor-associated factor 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Plasma Membrane Cell Surface Integral Component Of Membrane	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Angiogenesis Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Axon Extension Regulation Of Wound Healing Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Positive Regulation Of Cell Proliferation Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: PVR PVRL2 RAC1 SLC30A2 TNFSF12 TRAF1 TRAF2 TRAF3 TRAF5	42 interactors: CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GORASP2 LTBR MAP3K14 MAP3K5 MAVS MDM2 NGFRAP1 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 USP7 ZFAND6
Entrez ID		51330	7188
HPRD ID		05801	03834
Ensembl ID		ENSG00000006327	ENSG00000082512
Uniprot IDs		Q9NP84	D3DT93 O00463
PDB IDs		2EQP 2KMZ 2RPJ
Enriched GO Terms of Interacting Partners?		Susceptibility To T Cell Mediated Cytotoxicity Apoptotic Process Positive Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Susceptibility To Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Positive Regulation Of Cell Activation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Sequestering Of Zinc Ion Regulation Of Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Immune Response-regulating Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Cell Activation Signal Transduction Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Immune Response Signal Transduction Apoptotic Process Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of MAPK Cascade Cell Communication Cellular Response To Organic Substance Regulation Of Apoptotic Process Response To Stimulus Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Response To Cytokine Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Cytokine Stimulus Positive Regulation Of MAP Kinase Activity Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Response To Organic Substance Regulation Of Immunoglobulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Regulation Of Lymphocyte Activation Defense Response Positive Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud ?		2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction
Tagcloud (Difference) ?		2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction
Tagcloud (Intersection) ?