TIMMDC1 and PTPRN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	PTPRN
Description		translocase of inner mitochondrial membrane domain containing 1	protein tyrosine phosphatase receptor type N
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Axon Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse
	Molecular Function	Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Response To Reactive Oxygen Species Luteinization Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation
Pathways		Complex I biogenesis
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4
Entrez ID		51300	5798
HPRD ID		12817	03466
Ensembl ID		ENSG00000113845	ENSG00000054356
Uniprot IDs		C9JU35 Q9NPL8	Q16849 Q96IA0
PDB IDs			2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Membrane Structural Constituent Of Myelin Sheath Central Nervous System Myelination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?