PTPRN and SNX19

Number of citations of the paper that reports this interaction (PubMedID 16273344)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		PTPRN	SNX19
Description		protein tyrosine phosphatase receptor type N	sorting nexin 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Axon Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Response To Reactive Oxygen Species Luteinization Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation	Chondrocyte Differentiation Exocytosis Protein Transport Insulin Secretion Establishment Of Localization In Cell Dense Core Granule Maturation
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Pulse pressure ( 27841878 30224653 30578418) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260)
Interacting Genes		19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4	2 interacting genes: NOTCH3 PTPRN
Entrez ID		5798	399979
HPRD ID		03466	18621
Ensembl ID		ENSG00000054356	ENSG00000120451
Uniprot IDs		Q16849 Q96IA0	B7ZAU9 E9PJV7 E9PLV3 Q92543
PDB IDs		2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Membrane Structural Constituent Of Myelin Sheath Central Nervous System Myelination	Response To Anesthetic Ripoptosome Death Effector Domain Binding Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Death-inducing Signaling Complex Angiogenesis CD95 Death-inducing Signaling Complex Glomerular Capillary Formation Neuroblast Differentiation Dense Core Granule Maturation Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Pyroptotic Inflammatory Response Self Proteolysis Response To Cobalt Ion TRAIL-activated Apoptotic Signaling Pathway Luteinization Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macrophage Differentiation Death Receptor Binding Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Transcription Factor Binding Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Macrophage Differentiation Execution Phase Of Apoptosis Ubiquitin-like Protein Ligase Binding Spectrin Binding
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