TIMMDC1 and PIGF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	PIGF
Description		translocase of inner mitochondrial membrane domain containing 1	phosphatidylinositol glycan anchor biosynthesis class F
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Ethanolaminephosphotransferase Activity Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	GPI Anchor Biosynthetic Process
Pathways		Complex I biogenesis	Synthesis of glycosylphosphatidylinositol (GPI) Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20966902) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	10 interacting genes: AQP6 GPR152 LYVE1 MANBAL PIGG PIGO TIMMDC1 TMEM130 TMEM14B TMEM86B
Entrez ID		51300	5281
HPRD ID		12817	02539
Ensembl ID		ENSG00000113845	ENSG00000151665
Uniprot IDs		C9JU35 Q9NPL8	H7C392 Q07326 Q6IB04
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Mannose-ethanolamine Phosphotransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycerophospholipid Metabolic Process Nitrate Transmembrane Transporter Activity Glycolipid Biosynthetic Process Glycerolipid Metabolic Process CP2 Mannose-ethanolamine Phosphotransferase Activity D-lysine 5,6-aminomutase Activity Phospholipid Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Glycerophospholipid Biosynthetic Process Monoatomic Anion Channel Activity Renal Water Transport Ammonium Channel Activity Mitochondrial Membrane Membrane Lipid Metabolic Process Ammonium Transmembrane Transport Phospholipid Biosynthetic Process Hyaluronan Catabolic Process Water Channel Activity Phosphatidylcholine Acyl-chain Remodeling Carbon Dioxide Transport Carbohydrate Derivative Metabolic Process Transferase Activity, Transferring Phosphorus-containing Groups Positive Regulation Of Cellular Extravasation
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