TIMMDC1 and CYP4F12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	CYP4F12
Description		translocase of inner mitochondrial membrane domain containing 1	cytochrome P450 family 4 subfamily F member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Sodium Ion Homeostasis
Pathways		Complex I biogenesis	Fatty acids Eicosanoids
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Glioma ( 34319593) LDL cholesterol levels ( 32203549)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	5 interacting genes: CFTR HSPA6 MEOX2 SOD2 TIMMDC1
Entrez ID		51300	66002
HPRD ID		12817	07102
Ensembl ID		ENSG00000113845	ENSG00000186204
Uniprot IDs		C9JU35 Q9NPL8	Q9HCS2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Organic Hydroxy Compound Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Somite Specification Response To Magnetism Regulation Of Membrane Hyperpolarization Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Detection Of Oxygen Negative Regulation Of Membrane Hyperpolarization Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Response To Silicon Dioxide Response To L-ascorbic Acid Ethanolamine Transport Ethanolamine Transmembrane Transporter Activity Positive Regulation Of Tooth Mineralization Cellular Heat Acclimation Response To Superoxide Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Oxygen Radical Choline Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Choline Transport Response To Alcohol ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Intracellular Oxygen Homeostasis Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Response To Selenium Ion Amine Transport Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Response To Manganese Ion
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