PTPRN and CCDC134

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTPRN	CCDC134
Description		protein tyrosine phosphatase receptor type N	coiled-coil domain containing 134
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Axon Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Response To Reactive Oxygen Species Luteinization Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation	Angiogenesis Placenta Development Ventricular System Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Ossification Positive Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Embryonic Hemopoiesis Regulation Of Protein Glycosylation Embryonic Liver Development
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)	Alanine aminotransferase levels ( 33547301) Alzheimer's disease biomarkers ( 21123754) Intelligence (MTAG) ( 29326435) Meat-related diet ( 32066663) Plateletcrit ( 32888494) Processed meat consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4	4 interacting genes: PGRMC1 PTPRN TADA2A UBQLN4
Entrez ID		5798	79879
HPRD ID		03466	07988
Ensembl ID		ENSG00000054356	ENSG00000100147
Uniprot IDs		Q16849 Q96IA0	B0QY51 B4DRL0 Q9H6E4
PDB IDs		2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Membrane Structural Constituent Of Myelin Sheath Central Nervous System Myelination	Dense Core Granule Maturation Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Chromosome SAGA-type Complex Positive Regulation Of Lipoprotein Transport Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex
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