TIMMDC1 and IFNA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	IFNA2
Description		translocase of inner mitochondrial membrane domain containing 1	interferon alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Defense Response Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Complex I biogenesis	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs			Sifalimumab
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		51300	3440
HPRD ID		12817	00950
Ensembl ID		ENSG00000113845	ENSG00000188379
Uniprot IDs		C9JU35 Q9NPL8	P01563
PDB IDs			1ITF 1RH2 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Response To Interferon-alpha Cellular Response To Interferon-beta Response To Interferon-beta Cytokine Binding Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Interferon Receptor Activity Receptor Complex Response To Virus Cellular Response To Interferon-alpha Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Cellular Respiration Response To Cytokine Response To Peptide Mitochondrial Respiratory Chain Complex I Assembly NADH Dehydrogenase Complex Assembly Regulation Of Cellular Respiration Regulation Of Protein Localization Response To Other Organism Mitochondrial Respiratory Chain Complex Assembly Response To External Biotic Stimulus
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