TIMMDC1 and KIR2DL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	KIR2DL4
Description		translocase of inner mitochondrial membrane domain containing 1	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Endosome Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence
Pathways		Complex I biogenesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Objective response to lithium treatment ( 26503763)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6
Entrez ID		51300	3805
HPRD ID		12817	16082
Ensembl ID		ENSG00000113845	ENSG00000189013
Uniprot IDs		C9JU35 Q9NPL8	A0A0B4J1S6 A0A376A929 Q99706
PDB IDs			3WYR
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Mast Cell Apoptotic Process Serotonin Secretion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cytokine Production Involved In Immune Response B Cell Mediated Immunity Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Serotonin Secretion By Platelet Regulation Of Cytokine Production Involved In Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Adaptive Immune Response Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity CD8 Receptor Binding Tolerance Induction Dependent Upon Immune Response Peripheral B Cell Tolerance Induction MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Leukocyte Mediated Immunity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Negative Regulation Of G0 To G1 Transition Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation
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