TIMMDC1 and NINJ1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	NINJ1
Description		translocase of inner mitochondrial membrane domain containing 1	ninjurin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Extracellular Region Plasma Membrane Membrane Synapse Synaptic Membrane
	Molecular Function	Protein Binding	Lipopolysaccharide Binding Protein Binding Cell Adhesion Mediator Activity Membrane Destabilizing Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Angiogenesis Leukocyte Chemotaxis Involved In Inflammatory Response Inflammatory Response Cell Adhesion Nervous System Development Cytolysis Killing Of Cells Of Another Organism Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Tissue Regeneration Muscle Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Inflammatory Response Protein Homooligomerization Cellular Hyperosmotic Response Regulation Of Monocyte Chemotaxis Programmed Necrotic Cell Death Ferroptosis Pyroptotic Cell Death
Pathways		Complex I biogenesis
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Lactate dehydrogenase levels ( 29403010) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity (early onset extreme) ( 23563609)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	21 interacting genes: AQP6 ATP6AP2 CD200R1 CEACAM3 CREB3L1 CYB5R3 EBP FCGR1A FNDC9 GOLM1 GPX8 HIVEP1 KRT40 LIME1 MUC1 PVR SGCB TIMMDC1 TLCD4 TMEM14B TMEM31
Entrez ID		51300	4814
HPRD ID		12817	03639
Ensembl ID		ENSG00000113845	ENSG00000131669
Uniprot IDs		C9JU35 Q9NPL8	Q92982
PDB IDs			8CQR 8SZA 8UIP
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Membrane
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