TRIM59 and ZDHHC22

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		TRIM59	ZDHHC22
Description		tripartite motif containing 59	zDHHC palmitoyltransferase 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Cerebrospinal P-tau181p levels ( 28247064) Large artery stroke ( 24262325) Smoking status (ever vs never smokers) ( 30643258) Sweet taste preference ( 32572145)
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	14 interacting genes: CD79A CLEC4D CLSTN3 CREB3L1 FCRL2 FNDC9 GPX8 LDLRAD4 PVR RPRM TMEM14B TMEM86B TMEM88 TRIM59
Entrez ID		286827	283576
HPRD ID		15568	12655
Ensembl ID		ENSG00000213186	ENSG00000177108
Uniprot IDs		Q8IWR1	Q8N966
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress	Membrane
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