TRIM59 and UBE2J2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM59	UBE2J2
Description		tripartite motif containing 59	ubiquitin conjugating enzyme E2 J2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ERAD Pathway Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MARCHF6 MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		286827	118424
HPRD ID		15568	15600
Ensembl ID		ENSG00000213186	ENSG00000160087
Uniprot IDs		Q8IWR1	A6NGS0 Q8N2K1
PDB IDs			2F4W
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Protein Modification Process Proteolysis Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Proteasomal Protein Catabolic Process Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Ligase Complex Ligase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Autophagy Of Mitochondrion Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Manganese Ion Potassium Channel Inhibitor Activity Response To Oxidative Stress Protein K29-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Protein Localization Regulation Of Protein Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Exosomal Secretion
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