TRIM59

Description		tripartite motif containing 59
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Novel Interacting Genes		2 novel interacting genes: OTOL1 PPM1L
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		286827
HPRD ID		15568
Ensembl ID		ENSG00000213186
Uniprot IDs		Q8IWR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress
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