TRIM59 and SYVN1

Number of citations of the paper that reports this interaction (PubMedID 37740007)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TRIM59	SYVN1
Description		tripartite motif containing 59	synoviolin 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Immature B Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming
Pathways			XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Crohn's disease ( 32581322)
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	17 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 SLC35F2 TP53 TRIM59 UBE2D2 UBE2D3 UBE2G1 UBE2J1 UBE2U UBE2Z USP15 USP7
Entrez ID		286827	84447
HPRD ID		15568	07618
Ensembl ID		ENSG00000213186	ENSG00000162298
Uniprot IDs		Q8IWR1	Q86TM6
PDB IDs			6A3Z 8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Proteolysis Positive Regulation Of Amyloid Fibril Formation Ubiquitin Protein Ligase Binding Apoptotic Process Protein Metabolic Process Programmed Cell Death Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Endoplasmic Reticulum Protein-containing Complex Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Binding Transferase Activity Protein-folding Chaperone Binding Regulation Of Amyloid Fibril Formation Regulation Of Cellular Response To Stress K48-linked Deubiquitinase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Amyloid-beta Clearance Modification-dependent Protein Catabolic Process Response To Stress Negative Regulation Of Signal Transduction Release Of Cytochrome C From Mitochondria ATP Binding Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Molecular Function Activator Activity Deubiquitinase Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Macromolecule Metabolic Process Negative Regulation Of Cell Communication Glial Cell Proliferation Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Microglial Cell Activation Regulation Of Proteolysis
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