IFIT5 and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		IFIT5	ECSIT
Gene Name		interferon-induced protein with tetratricopeptide repeats 5	ECSIT signalling integrator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Ruffle Membrane Apical Part Of Cell	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	TRNA Binding RNA Binding Single-stranded RNA Binding Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Innate Immune Response Defense Response To Virus	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: A2M APOE CDC37 ECSIT IFIT1 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		24138	51295
HPRD ID		17130	12225
Ensembl ID		ENSG00000152778	ENSG00000130159
Uniprot IDs		B4DDV1 Q13325	K7EMM0 Q9BQ95
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Response To Stress Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Cellular Response To Stimulus Negative Regulation Of Viral Process Immune Response Innate Immune Response Response To Stimulus Regulation Of Neuron Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Protein Binding Regulation Of Neuron Death Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nuclear Speck Organization Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of MRNA Splicing, Via Spliceosome Defense Response Signal Transduction Immune System Process Positive Regulation Of Neuron Death Regulation Of Oxidoreductase Activity Regulation Of Cellular Process Regulation Of Apoptotic Process Protein Metabolic Process Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of MRNA Processing Regulation Of Cell Death Signaling Regulation Of Catalytic Activity Negative Regulation Of Binding Negative Regulation Of Apoptotic Process Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of RNA Splicing Response To Oxidative Stress Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding expand ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding expand ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?