IFIT5 and H19

Number of citations of the paper that reports this interaction (PubMedID 37298108)
45

Data Source:
BioGRID (unspecified method)

		IFIT5	H19
Description		interferon induced protein with tetratricopeptide repeats 5	H19 imprinted maternally expressed transcript
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane IkappaB Kinase Complex Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Apical Part Of Cell
	Molecular Function	TRNA Binding RNA Cap Binding Double-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding
	Biological Process	Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus
Pathways		Interferon alpha/beta signaling
Drugs
Diseases			Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome
GWAS			Celiac disease ( 23936387) Creatinine levels ( 29403010) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (parent-of-origin) ( 23725790) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hypertension ( 30487518) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		16 interacting genes: A2M APOE CDC37 ECSIT H19 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2 TTC3	21 interacting genes: BCLAF1 DDX5 DSP ESRP1 FMR1 IFIT5 ILF2 MYO1D NSD2 PCCA PCCB PPP1R3E PRKRA SERBP1 SRSF10 SRSF8 SRSF9 SSB STON2 TPM1 U2SURP
Entrez ID		24138	283120
HPRD ID		17130
Ensembl ID		ENSG00000152778	ENSG00000130600
Uniprot IDs		Q13325
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Antioxidant Activity Amyloid Precursor Protein Metabolic Process Regulation Of Viral Process Regulation Of Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Response To Stress Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Magnesium Ion Binding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Respiratory Burst Involved In Inflammatory Response Oxidation-dependent Protein Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle HSP90-CDC37 Chaperone Complex Regulation Of Blood Coagulation Regulation Of Hemostasis	RNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing Propionyl-CoA Carboxylase Activity Regulation Of MRNA Metabolic Process Poly(U) RNA Binding RNA Splicing MRNA Metabolic Process MRNA Processing Short-chain Fatty Acid Catabolic Process Ribonucleoprotein Complex SiRNA Binding Sequence-specific MRNA Binding Nuclear Speck Translation Repressor Activity Short-chain Fatty Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression Regulation Of Viral Life Cycle Catalytic Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Branched-chain Amino Acid Metabolic Process MRNA Catabolic Process Negative Regulation Of RNA Splicing MRNA 3'-UTR Binding Regulation Of Viral Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus MRNA Splice Site Recognition MiRNA Processing Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MiRNA Transcription Positive Regulation Of Intracellular Transport Of Viral Material Ligase Activity, Forming Carbon-carbon Bonds Nuclear Histone MRNA Catabolic Process Positive Regulation Of Heart Rate By Epinephrine Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Primary Metabolic Process RNA Catabolic Process Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Metabolic Process
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