HERC5 and UBE2L6

Number of citations of the paper that reports this interaction (PubMedID 20308324)
58

Data Source:
BioGRID (pull down)

		HERC5	UBE2L6
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 5	ubiquitin conjugating enzyme E2 L6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ISG15-protein Conjugation PKR/eIFalpha Signaling Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Protein Modification Process Innate Immune Response
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NLRP3 NME2 PITX2 RNF10 STK38 UBE2E2 UBE2L6	44 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 ITCH LONRF1 MAP3K1 MID1 MUL1 NEDD4 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM13 TRIM25 TRIM27 TRIM28 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A YAP1
Entrez ID		51191	9246
HPRD ID		10502	04867
Ensembl ID		ENSG00000138646	ENSG00000156587
Uniprot IDs		B4DXV3 Q9UII4	O14933
PDB IDs		8Y4Z	1WZV 1WZW 2KJH 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Microtubule Organizing Center Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Cell Cycle Process Nucleus Mitotic Cell Cycle Phase Transition Cellular Response To Stress Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Binding Cell Division Positive Regulation Of Cell Cycle Process Response To Iron Ion Positive Regulation Of Cell Cycle Phase Transition Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process ISG15 Transferase Activity Positive Regulation Of Mitotic Cell Cycle Regeneration Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle ISG15-protein Conjugation Response To Stress Cytoplasm Regulation Of Macromolecule Biosynthetic Process Response To Vitamin E Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Transferase Activity Proteolysis Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Monoubiquitination Suppression Of Viral Release By Host Protein K63-linked Ubiquitination Protein Autoubiquitination Transcription Coactivator Activity Innate Immune Response Negative Regulation Of Viral Transcription Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Viral Transcription SUMO Transferase Activity Cytoplasm Defense Response To Symbiont Defense Response To Other Organism Protein K6-linked Ubiquitination Defense Response To Virus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Negative Regulation Of Viral Process Regulation Of Viral Process Ubiquitin-like Modifier Activating Enzyme Activity Response To Other Organism Protein K29-linked Ubiquitination Positive Regulation Of Cell Communication
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