HERC5 and NME2

Number of citations of the paper that reports this interaction (PubMedID 18535780)
0

Data Source:
HPRD (in vivo)

		HERC5	NME2
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 5	NME/NM23 nucleoside diphosphate kinase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Focal Adhesion Lamellipodium Secretory Granule Lumen Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding DNA-binding Transcription Activator Activity DNA Binding Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ISG15-protein Conjugation PKR/eIFalpha Signaling Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Integrin-mediated Signaling Pathway Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II ITP Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	Interconversion of nucleotide di- and triphosphates Neutrophil degranulation Azathioprine ADME Ribavirin ADME
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)
Interacting Genes		16 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NLRP3 NME2 PITX2 RNF10 STK38 UBE2E2 UBE2L6	18 interacting genes: BNIPL CEBPA CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		51191	4831
HPRD ID		10502	01132
Ensembl ID		ENSG00000138646	ENSG00000243678
Uniprot IDs		B4DXV3 Q9UII4	F6XY72 P22392 Q6FHN3
PDB IDs		8Y4Z	1NSK 1NUE 3BBB 3BBC 3BBF 7KPF 8PIE 8PYW
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Microtubule Organizing Center Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Cell Cycle Process Nucleus Mitotic Cell Cycle Phase Transition Cellular Response To Stress Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Binding Cell Division Positive Regulation Of Cell Cycle Process Response To Iron Ion Positive Regulation Of Cell Cycle Phase Transition Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process ISG15 Transferase Activity Positive Regulation Of Mitotic Cell Cycle Regeneration Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle ISG15-protein Conjugation Response To Stress Cytoplasm Regulation Of Macromolecule Biosynthetic Process Response To Vitamin E Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Macromolecule Biosynthetic Process	White Fat Cell Differentiation Regulation Of Vesicle Size GDP Binding FAR/SIN/STRIPAK Complex Synaptic Vesicle Recycling Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Transcription Coregulator Binding Clathrin Coat Assembly Involved In Endocytosis Mitochondrial Outer Membrane Fusion Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Transcription Corepressor Binding Cellular Response To Lipid Nuclear Receptor Activity
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