HERC5 and MTDH

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		HERC5	MTDH
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 5	metadherin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ISG15-protein Conjugation PKR/eIFalpha Signaling Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)
Interacting Genes		16 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NLRP3 NME2 PITX2 RNF10 STK38 UBE2E2 UBE2L6	175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC
Entrez ID		51191	92140
HPRD ID		10502	17459
Ensembl ID		ENSG00000138646	ENSG00000147649
Uniprot IDs		B4DXV3 Q9UII4	Q86UE4
PDB IDs		8Y4Z	4QMG
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Microtubule Organizing Center Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Cell Cycle Process Nucleus Mitotic Cell Cycle Phase Transition Cellular Response To Stress Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Binding Cell Division Positive Regulation Of Cell Cycle Process Response To Iron Ion Positive Regulation Of Cell Cycle Phase Transition Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process ISG15 Transferase Activity Positive Regulation Of Mitotic Cell Cycle Regeneration Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle ISG15-protein Conjugation Response To Stress Cytoplasm Regulation Of Macromolecule Biosynthetic Process Response To Vitamin E Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Macromolecule Biosynthetic Process	Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway
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