DNM3

Description		dynamin 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Postsynaptic Density Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Endocytosis Synapse Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Filopodium Assembly
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 28869591 30598549) Height ( 28552196 20881960 23563607 25282103 25429064 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29083408) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Mean platelet volume ( 27863252 32888494 24026423 22139419 19820697) Ovarian cancer ( 30557369) Platelet count ( 33545615 29403010 32888494 22139419 27863252) Platelet distribution width ( 32888494 27863252) QT interval (sulfonylurea treatment interaction) ( 27958378) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Uterine fibroids ( 31249589) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		6 interacting genes: DYNLL1 DYRK1A HOMER1 HSPA13 PCNT SNCA
Entrez ID		26052
HPRD ID		13241
Ensembl ID		ENSG00000197959
Uniprot IDs		H0YBC6 Q9UQ16
PDB IDs		3L43 5A3F
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Microtubule Polymerization Behavioral Response To Cocaine Regulation Of Microtubule Polymerization Axon Microtubule Regulation Of Amide Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Histone H3T45 Kinase Activity Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Enzyme Inhibitor Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Tetramerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Calcium Ion Transport Cytoskeleton Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Centrosome Negative Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Intracellular Transport Regulation Of Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity G Protein-coupled Glutamate Receptor Binding Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Heterochromatin Formation Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Monoatomic Ion Transport Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly
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