APH1A and CEP350

		APH1A	CEP350
Description		aph-1A gamma-secretase subunit	centrosomal protein 350
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GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Protein Binding Microtubule Binding
	Biological Process	Metanephros Development Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process	Microtubule Anchoring Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs		E-2012 MK-0752
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Morning vs. evening chronotype ( 26835600 26955885) Refractive error ( 32231278) Schizophrenia ( 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anorexia nervosa ( 23568457) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Smoking initiation ( 30617275)
Interacting Genes		36 interacting genes: ANKRD46 APOD ASGR1 ATF4 BHLHE40 CREB3 DRD2 FIS1 FXYD6 GLP1R GPATCH8 GPR35 HES1 HIVEP1 IGFBP5 KLF11 LAT MFSD6 MPP1 MRAP2 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 SCAND1 SERP1 SLC38A7 SLC39A9 SMAGP THPO TLE1 TMED10 TMEM140 TMEM218 TRARG1	7 interacting genes: APP APTX NR1H3 PLEKHA5 PPARA PPARD PPARG
Entrez ID		51107	9857
HPRD ID		06360	09870
Ensembl ID		ENSG00000117362	ENSG00000135837
Uniprot IDs		B4DUG7 Q96BI3	Q5T2X4 Q5VT06
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8X52 8X53 8X54	2COZ
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid Precursor Protein Metabolic Process Presynaptic Membrane Membrane Protein Proteolysis Notch Signaling Pathway Cajal-Retzius Cell Differentiation Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Growth Factor Receptor Binding Regulation Of Transport Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Membrane CAMP Response Element Binding Protein Binding Regulation Of Protein Metabolic Process Negative Regulation Of Transport Homeostatic Process Regulation Of Growth Hormone Secretion Membrane Protein Intracellular Domain Proteolysis Golgi Membrane Synaptic Membrane Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Signal Transduction Vesicle Targeting Epithelial Cell Proliferation Protein Processing Endopeptidase Activator Activity Regulation Of Primary Metabolic Process Regulation Of Synaptic Plasticity G Protein-coupled Dopamine Receptor Signaling Pathway Cerebral Cortex Neuron Differentiation	Negative Regulation Of Cholesterol Storage Negative Regulation Of Lipid Storage Negative Regulation Of MiRNA Transcription Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Small Molecule Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Lipid Storage Nuclear Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Ketone Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Cellular Response To Oxygen-containing Compound Negative Regulation Of Type II Interferon-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Defense Response Peroxisome Proliferator Activated Receptor Signaling Pathway Fatty Acid Metabolic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Lipid Transport Nuclear Steroid Receptor Activity Regulation Of Defense Response Negative Regulation Of RNA Metabolic Process Response To Nutrient Regulation Of Protein Transport Positive Regulation Of Cholesterol Efflux Negative Regulation Of Myoblast Differentiation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Growth Sequence-specific DNA Binding Monocarboxylic Acid Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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