TANC1 and SPTAN1

Number of citations: 0 (PubMedID 15673434)
Data Source: HPRD (in vitro, in vivo)

		TANC1	SPTAN1
Name		tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	spectrin alpha, non-erythrocytic 1
Structure		No pdb structure
GO Annotations	Cellular Component	Postsynaptic Density Dendrite Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Myoblast Fusion Visual Learning Dendritic Spine Maintenance Regulation Of Postsynapse Organization	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		None	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Diseases		None	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 28869591 30598549 ) Nicotine dependence ( 28440896 ) Night sleep phenotypes ( 27126917 ) Response to radiotherapy in prostate cancer (toxicity) ( 24974847 ) Resting heart rate ( 27798624 ) Restless legs syndrome ( 29029846 ) Tourette syndrome ( 30818990 )	Axial length ( 24144296 ) Body mass index ( 26426971 )
Novel Interactors		None recorded	3 novel interactors: C5 CNTRL TRAF1
Interacting Genes		12 interacting genes: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333
Entrez ID		85461	6709
HPRD ID		18146	01684
Ensembl ID		ENSG00000115183	ENSG00000197694
Uniprot IDs		B9EK39 Q9C0D5	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs		Not available	2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
GO Terms Enriched among Interactors		Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Glutamate Receptor Signaling Pathway Neuron Projection Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Neuron Spine Ligand-gated Ion Channel Signaling Pathway Glutamatergic Synapse Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Dendritic Spine Trans-synaptic Signaling Synaptic Signaling Synaptic Membrane Regulation Of Monoatomic Ion Transport Protein Localization To Cell Junction Dendrite Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Regulation Of Nervous System Process Excitatory Synapse Structural Constituent Of Postsynaptic Density Cell-cell Signaling Regulation Of Transport Signaling Positive Regulation Of Synaptic Transmission Cell Communication Maintenance Of Postsynaptic Density Structure Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Monoatomic Ion Transport Long-term Synaptic Potentiation Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Protein Localization To Synapse Cell Junction Cell-cell Junction Regulation Of Synaptic Plasticity Glutamate Receptor Binding Postsynapse Scaffold Protein Binding Postsynaptic Membrane GMP Kinase Activity Glutamate-gated Calcium Ion Channel Activity Endocytic Vesicle Membrane Maintenance Of Postsynaptic Specialization Structure Neuromuscular Junction	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite