TANC1 and GRIA1

Number of citations of the paper that reports this interaction (PMID 15673434)
1

Data Source:
HPRD (in vivo)

		TANC1	GRIA1
Gene Name		tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	glutamate receptor, ionotropic, AMPA 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Axon Terminus Postsynaptic Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome
	Molecular Function		Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding
	Biological Process	Myoblast Fusion Visual Learning Dendritic Spine Maintenance	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression
Pathways			Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS			Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		12 interactors: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1	22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1
Entrez ID		85461	2890
HPRD ID		18146	00695
Ensembl ID		ENSG00000115183	ENSG00000155511
Uniprot IDs		B9EK39 Q9C0D5	P42261 Q59GL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Protein Localization To Synapse Cell-cell Signaling Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Ion Transport Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Synaptic Plasticity Regulation Of Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Single-organism Behavior Positive Regulation Of Ion Transport Nucleotide Phosphorylation Neuron Development Axonogenesis Glutamate Receptor Signaling Pathway Axon Development Regulation Of Excitatory Postsynaptic Membrane Potential Receptor Localization To Synapse Cell Morphogenesis Regulation Of Postsynaptic Membrane Potential Behavior Chemotaxis Learning Or Memory Regulation Of Membrane Potential Neuron Differentiation Cell Development Cell Projection Organization Cognition Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission Dendritic Spine Morphogenesis System Development Vocalization Behavior Membrane Depolarization Memory Dendritic Spine Development Neuromuscular Process Nervous System Development Learning Regulation Of Ion Transmembrane Transporter Activity Dendritic Spine Organization Regulation Of Transmembrane Transporter Activity Cell Differentiation Generation Of Neurons Multicellular Organismal Development Regulation Of Calcium Ion Import	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death
Tagcloud ?			acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?			acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?