TANC1 and GRIA1

Number of citations: 0 (PubMedID 15673434)
Data Source: HPRD (in vivo)

		TANC1	GRIA1
Name		tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	glutamate ionotropic receptor AMPA type subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Postsynaptic Density Dendrite Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse	Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Synaptic Vesicle Ionotropic Glutamate Receptor Complex External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Early Endosome Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Somatodendritic Compartment Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Cell Body Axonal Spine Neuron Spine Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component Perisynaptic Space Proximal Dendrite
	Molecular Function	Protein Binding	Amyloid-beta Binding G-protein Alpha-subunit Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Adenylate Cyclase Binding Ligand-gated Monoatomic Ion Channel Activity Immunoglobulin Binding Protein Kinase Binding Protein Domain Specific Binding Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Small GTPase Binding Myosin V Binding G-protein Beta-subunit Binding Beta-2 Adrenergic Receptor Binding Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein Kinase A Binding Peptide Hormone Receptor Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Myoblast Fusion Visual Learning Dendritic Spine Maintenance Regulation Of Postsynapse Organization	Regulation Of Receptor Recycling Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synapse Assembly Long-term Memory Response To Xenobiotic Stimulus Response To Toxic Substance Response To Sucrose Response To Lithium Ion Positive Regulation Of Gene Expression Neuronal Action Potential Calcium-mediated Signaling Spinal Cord Development Cerebral Cortex Development Receptor Internalization Response To Nutrient Levels Response To Estradiol Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Cocaine Response To Morphine Response To Peptide Hormone Response To Ethanol Positive Regulation Of Membrane Potential Response To Arsenic-containing Substance Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Response To Electrical Stimulus Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Long-term Synaptic Depression Response To Fungicide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To DsRNA Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Amine Stimulus Positive Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Presynaptic Membrane Potential Cellular Response To L-glutamate Cellular Response To Brain-derived Neurotrophic Factor Stimulus Conditioned Place Preference Response To Psychosocial Stress Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		None	COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation
Drugs		None	Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)
GWAS		Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 28869591 30598549 ) Nicotine dependence ( 28440896 ) Night sleep phenotypes ( 27126917 ) Response to radiotherapy in prostate cancer (toxicity) ( 24974847 ) Resting heart rate ( 27798624 ) Restless legs syndrome ( 29029846 ) Tourette syndrome ( 30818990 )	Adult body size ( 32376654 ) Aging (time to event) ( 21782286 ) Anthropometric traits ( 19260139 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726 ) Chronotype ( 30696823 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Interleukin-6 levels ( 22205395 ) Middle childhood and early adolescence aggressive behavior ( 26087016 ) Morning person ( 30696823 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Schizophrenia ( 30285260 28991256 25056061 23974872 ) Sleep (1/3-day periodicity) ( 33075057 ) Sudden cardiac arrest ( 21658281 ) Survival in microsatellite instability low/stable colorectal cancer ( 25866641 )
Novel Interactors		None recorded	1 novel interactors: FLT4
Interacting Genes		12 interacting genes: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1	27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 CYLD DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46
Entrez ID		85461	2890
HPRD ID		18146	00695
Ensembl ID		ENSG00000115183	ENSG00000155511
Uniprot IDs		B9EK39 Q9C0D5	A0A9L9PXG3 P42261 Q59GL5
PDB IDs		Not available	6X5Q
GO Terms Enriched among Interactors		Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Glutamate Receptor Signaling Pathway Neuron Projection Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Neuron Spine Ligand-gated Ion Channel Signaling Pathway Glutamatergic Synapse Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Dendritic Spine Trans-synaptic Signaling Synaptic Signaling Synaptic Membrane Regulation Of Monoatomic Ion Transport Protein Localization To Cell Junction Dendrite Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Regulation Of Nervous System Process Excitatory Synapse Structural Constituent Of Postsynaptic Density Cell-cell Signaling Regulation Of Transport Signaling Positive Regulation Of Synaptic Transmission Cell Communication Maintenance Of Postsynaptic Density Structure Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Monoatomic Ion Transport Long-term Synaptic Potentiation Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Protein Localization To Synapse Cell Junction Cell-cell Junction Regulation Of Synaptic Plasticity Glutamate Receptor Binding Postsynapse Scaffold Protein Binding Postsynaptic Membrane GMP Kinase Activity Glutamate-gated Calcium Ion Channel Activity Endocytic Vesicle Membrane Maintenance Of Postsynaptic Specialization Structure Neuromuscular Junction	Synapse Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Protein Localization To Cell Periphery Postsynaptic Density Regulation Of Protein Localization Neuron Projection Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Ionotropic Glutamate Receptor Binding Regulation Of Transport Regulation Of Protein Localization To Membrane Regulation Of Biological Quality Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Plasma Membrane Regulation Of Apoptotic Process Regulation Of Metal Ion Transport Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization Intracellular Signaling Cassette Dendrite Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Programmed Cell Death Intracellular Protein Localization Proteolysis Involved In Protein Catabolic Process Proteolysis Chemical Synaptic Transmission AMPA Glutamate Receptor Complex Trans-synaptic Signaling Cortical Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Complex Regulation Of Cellular Localization Protein Phosphorylation Synaptic Signaling Establishment Of Protein Localization Protein Localization To Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Postsynapse