TANC1 and GRIN2B

Number of citations of the paper that reports this interaction (PMID 15673434)
1

Data Source:
HPRD (in vivo)

		TANC1	GRIN2B
Gene Name		tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Axon Terminus Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function		N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding
	Biological Process	Myoblast Fusion Visual Learning Dendritic Spine Maintenance	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways			EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine
Diseases
GWAS			Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)
Protein-Protein Interactions		12 interactors: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1	40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		85461	2904
HPRD ID		18146	00697
Ensembl ID		ENSG00000115183
Uniprot IDs		B9EK39 Q9C0D5	Q13224
PDB IDs			1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Protein Localization To Synapse Cell-cell Signaling Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Ion Transport Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Synaptic Plasticity Regulation Of Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Single-organism Behavior Positive Regulation Of Ion Transport Nucleotide Phosphorylation Neuron Development Axonogenesis Glutamate Receptor Signaling Pathway Axon Development Regulation Of Excitatory Postsynaptic Membrane Potential Receptor Localization To Synapse Cell Morphogenesis Regulation Of Postsynaptic Membrane Potential Behavior Chemotaxis Learning Or Memory Regulation Of Membrane Potential Neuron Differentiation Cell Development Cell Projection Organization Cognition Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission Dendritic Spine Morphogenesis System Development Vocalization Behavior Membrane Depolarization Memory Dendritic Spine Development Neuromuscular Process Nervous System Development Learning Regulation Of Ion Transmembrane Transporter Activity Dendritic Spine Organization Regulation Of Transmembrane Transporter Activity Cell Differentiation Generation Of Neurons Multicellular Organismal Development Regulation Of Calcium Ion Import	Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation
Tagcloud ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?