FOXP3 and RUNX1

Number of citations of the paper that reports this interaction (PMID 17377532)
123

Data Source:
HPRD (in vitro, in vivo)

		FOXP3	RUNX1
Gene Name		forkhead box P3	runt-related transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Protein Complex	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter B Cell Homeostasis Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Mediated Immunity Tolerance Induction To Self Antigen Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Cytokine Biosynthetic Process T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cytokine Secretion Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion
Pathways
Drugs
Diseases
GWAS			Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		9 interactors: EP300 IKZF4 KAT8 NFAT5 NFATC2 PRR20A RBPMS RUNX1 STUB1	46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1
Entrez ID		50943	861
HPRD ID		02242	01043
Ensembl ID		ENSG00000049768	ENSG00000159216
Uniprot IDs		Q9BZS1	Q01196
PDB IDs		3QRF	1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H2B Acetylation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Negative Regulation Of Gene Expression ER-nucleus Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Topologically Incorrect Protein Histone Acetylation Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Progesterone Secretion Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Response To Unfolded Protein Protein Acetylation Regulation Of Signal Transduction Cytokine Production N-terminal Peptidyl-lysine Acetylation Regulation Of Progesterone Secretion	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance
Tagcloud ?		17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Difference) ?		17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Intersection) ?