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FOXP3 and NFATC2
Number of citations of the paper that reports this interaction (PubMedID
19564342
)
34
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo)
FOXP3
NFATC2
Description
forkhead box P3
nuclear factor of activated T cells 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Transcription Factor AP-1 Complex
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
Metal Ion Binding
NF-kappaB Binding
NFAT Protein Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Phosphatase Binding
Sequence-specific DNA Binding
Molecular Adaptor Activity
14-3-3 Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
B Cell Homeostasis
Negative Regulation Of Cytokine Production
Myeloid Cell Homeostasis
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment
T Cell Mediated Immunity
Tolerance Induction
Tolerance Induction To Self Antigen
T Cell Tolerance Induction
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Tolerance Induction
Regulation Of T Cell Anergy
Positive Regulation Of T Cell Anergy
Negative Regulation Of Chronic Inflammatory Response
Negative Regulation Of T Cell Cytokine Production
Positive Regulation Of Peripheral T Cell Tolerance Induction
T Cell Anergy
Chromatin Remodeling
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Inflammatory Response
Negative Regulation Of Cell Population Proliferation
Response To Virus
Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Establishment Of Endothelial Blood-brain Barrier
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-4 Production
Negative Regulation Of Interleukin-5 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-4 Production
Negative Regulation Of CREB Transcription Factor Activity
Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
Transforming Growth Factor Beta1 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Immature T Cell Proliferation In Thymus
Positive Regulation Of Immature T Cell Proliferation In Thymus
CD4-positive, Alpha-beta T Cell Proliferation
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
T Cell Homeostasis
CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulatory T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Activated T Cell Proliferation
Alpha-beta T Cell Proliferation
Negative Regulation Of Alpha-beta T Cell Proliferation
Lymphocyte Proliferation
Isotype Switching To IgE Isotypes
Negative Regulation Of Isotype Switching To IgE Isotypes
Regulation Of Isotype Switching To IgG Isotypes
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Defense Response To Virus
Negative Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Response To Rapamycin
Negative Regulation Of T-helper 17 Cell Differentiation
Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
DNA Damage Response
Response To Xenobiotic Stimulus
Gene Expression
Positive Regulation Of Gene Expression
Myotube Cell Development
Cell Migration
Positive Regulation Of B Cell Proliferation
Calcineurin-NFAT Signaling Cascade
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
B Cell Receptor Signaling Pathway
Cartilage Development
Cellular Response To Calcium Ion
LncRNA Transcription
Positive Regulation Of Myoblast Fusion
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates transcription of genes involved in WNT signaling
Calcineurin activates NFAT
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
Permanent neonatal diabetes mellitus (PNDM)
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Vitiligo (
27723757
)
A body shape index (
34021172
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asparaginase hypersensitivity in acute lymphoblastic leukemia (
25987655
)
Asthma (
32296059
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
27863252
32888494
)
Height (
28552196
)
Lymphocyte count (
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (calcium channel blockers) (
31015401
)
Medication use (diuretics) (
31015401
)
Molar-incisor hypomineralization (
23918034
)
Self-reported allergy (
23817569
)
Sitting height ratio (
25865494
)
Sum eosinophil basophil counts (
27863252
)
Systolic blood pressure (
30224653
)
Tourette's syndrome or obsessive-compulsive disorder (
25158072
)
Type 2 diabetes (
30718926
32499647
)
Urinary uric acid excretion (
31993563
)
Weight (
28552196
)
White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) (
28924203
)
Interacting Genes
18 interacting genes:
EP300
FOSB
IKZF4
KAT8
KRTAP3-3
KRTAP6-2
KRTAP8-1
MDM2
NFAT5
NFATC2
NLK
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RBPMS
RUNX1
20 interacting genes:
CREBBP
EGR1
EGR4
EP300
FOXP3
IRF2BP2
IRF4
MED31
MEF2D
NFATC2IP
NRON
PIN1
PPP3CB
PPP3R1
PRKCZ
SOCS3
TAF9
VIM
YWHAQ
YWHAZ
Entrez ID
50943
4773
HPRD ID
02242
02730
Ensembl ID
ENSG00000049768
ENSG00000101096
Uniprot IDs
Q9BZS1
B5B2P4
Q13469
PDB IDs
3QRF
4WK8
1A02
1OWR
1P7H
1PZU
1S9K
2AS5
2O93
3QRF
8OW4
8R07
8R3F
Enriched GO Terms of Interacting Partners
?
Protein Propionyltransferase Activity
DNA-binding Transcription Factor Binding
Pre-mRNA Intronic Binding
Histone H4 Acetyltransferase Activity
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Acetyltransferase Activity
Transcription By RNA Polymerase II
Calcineurin-NFAT Signaling Cascade
Positive Regulation Of RNA Metabolic Process
Histone Acetyltransferase Complex
Protein-lysine-acetyltransferase Activity
Negative Regulation Of RNA Metabolic Process
Calcineurin-mediated Signaling
Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Histone Acetyltransferase Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Intermediate Filament
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Hemopoiesis
DNA-templated Transcription
Positive Regulation Of Receptor Signaling Pathway Via STAT
Peptidyl-lysine Propionylation
Swimming
Histone Lactyltransferase (CoA-dependent) Activity
Peptidyl-lysine Butyrylation
Peptidyl-lysine Crotonylation
Histone H3K122 Acetyltransferase Activity
Histone Butyryltransferase Activity
Histone Crotonyltransferase Activity
Response To Cocaine
Response To Formaldehyde
Cellular Response To Vitamin B1
Positive Regulation Of Gene Expression
Cellular Response To Osmotic Stress
Transcription Coactivator Binding
Transcription Initiation-coupled Chromatin Remodeling
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Regulation Of Protein Processing
Positive Regulation Of Alpha-beta T Cell Differentiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
CD4-positive, Alpha-beta T Cell Lineage Commitment
Positive Regulation Of Biosynthetic Process
Alpha-beta T Cell Lineage Commitment
Positive Regulation Of RNA Metabolic Process
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Macromolecule Metabolic Process
T Cell Lineage Commitment
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of T-helper Cell Differentiation
T-helper 17 Cell Lineage Commitment
Positive Regulation Of Metabolic Process
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Regulation Of Protein Localization To Nucleus
T-helper Cell Lineage Commitment
Histone H3K27 Acetyltransferase Activity
Mononuclear Cell Differentiation
DNA-binding Transcription Factor Binding
Nucleoplasm
Regulation Of CD4-positive, Alpha-beta T Cell Activation
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Peptide Lactyltransferase (CoA-dependent) Activity
Positive Regulation Of Interleukin-4 Production
Leukocyte Differentiation
Histone Acetyltransferase Activity
Regulation Of Interleukin-4 Production
Lymphocyte Differentiation
Lymphocyte Activation
Regulation Of Alpha-beta T Cell Activation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Tau Protein Binding
Phosphoserine Residue Binding
Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Calcineurin Complex
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Cell Differentiation
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