FOXP3 and PRR20D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXP3	PRR20D
Description		forkhead box P3	proline rich 20D
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction Tolerance Induction To Self Antigen T Cell Tolerance Induction Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction T Cell Anergy Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Virus Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Transforming Growth Factor Beta1 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Proliferation Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Vitiligo ( 27723757)	Smoking initiation ( 33082346)
Interacting Genes		18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1	89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20B PRR20C PRR20E PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683
Entrez ID		50943	729246
HPRD ID		02242	19670
Ensembl ID		ENSG00000049768	ENSG00000227151
Uniprot IDs		Q9BZS1	P86478 P86479 P86480 P86481 P86496
PDB IDs		3QRF 4WK8
Enriched GO Terms of Interacting Partners?		Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Pre-mRNA Intronic Binding Histone H4 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Transcription By RNA Polymerase II Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Calcineurin-mediated Signaling Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Hemopoiesis DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Cocaine Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Gene Expression Cellular Response To Osmotic Stress Transcription Coactivator Binding Transcription Initiation-coupled Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation	Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Splicing Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MRNA Splicing, Via Spliceosome Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Myoblast Fate Commitment Nucleoplasm Regulation Of MRNA Metabolic Process MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Axis Specification U1 SnRNP Binding RNA Splicing
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