FOXP3 and KRTAP6-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXP3	KRTAP6-2
Description		forkhead box P3	keratin associated protein 6-2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytosol Intermediate Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction Tolerance Induction To Self Antigen T Cell Tolerance Induction Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction T Cell Anergy Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Virus Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Transforming Growth Factor Beta1 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Proliferation Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Keratinization
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling	Keratinization
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1	186 interacting genes: ADAM12 ADAMTSL4 ANAPC11 ANKS1A ANXA11 APOBEC1 AQP1 ARID5A ATG9A ATN1 ATOSB ATPAF2 BEX2 BHLHE40 C10orf55 C1orf94 C6orf15 CAMK2A CAMK2B CASC3 CATSPER1 CCDC120 CCDC17 CCDC28A-AS1 CCER1 CCNK CELF5 CERCAM CERK CFP CHIC2 CIMIP1 CIMIP2B COL8A1 CREB5 CTRC CYSRT1 DAZAP2 DHRS1 DMRT3 ENKD1 ESR2 FAAP20 FAM168A FAM83A FOXD2 FOXD4L1 FOXD4L3 FOXP3 FRS3 GALT GATA3 GCM2 GLIS2 GLYCTK GNE GPS2 GRINA GRN GSTP1 HAPLN2 HELT HEY1 HEY2 HEYL HHEX HOXA1 HOXB9 HOXC8 HOXC9 HSF4 HYAL2 IGFN1 INCA1 INO80B ITGB4 KLHL38 KPRP KRT83 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP6-3 LASP1 LCE2B LCE2D LCE5A LETM1 LGALS9C LRFN4 LRRC41 LYVE1 MEIS2 MGAT5B MKRN3 NAF1 NDUFA9 NEU4 NFKBID NID2 NPBWR2 NR1D2 NSD1 OLIG3 OTX1 OXER1 PATL1 PATZ1 PAX3 PDP1 PHLDA1 PITX1 PKD2 PLEKHN1 PLSCR4 POGZ POU5F2 PRR13 PRR3 PRR30 PRR35 RASD1 RBFOX2 RBPMS2 RERE RHOXF2 RNF38 ROR2 RTP5 RUNX1T1 RUSC1 SAMD7 SAXO4 SHARPIN SIAH3 SMAP2 SMARCC1 SMN1 SMN2 SMUG1 SNRPB SNRPC SPAG8 SPATA8 SPMIP9 TBX6 TCF7L2 TEKT3 TEKT4 TEKT5 TENT5B TENT5D TEPSIN TFAP2D TLE5 TLX2 TLX3 TNIP1 TOLLIP TPRX1 TRIP13 TSGA10IP TSPAN4 TSPYL6 VAC14 VENTX VGLL3 VPS37C YPEL3 ZBTB32 ZC3H10 ZIC1 ZNF414 ZNF503 ZNF581 ZNF683 ZNF843
Entrez ID		50943	337967
HPRD ID		02242	11219
Ensembl ID		ENSG00000049768	ENSG00000186930
Uniprot IDs		Q9BZS1	Q3LI66
PDB IDs		3QRF 4WK8
Enriched GO Terms of Interacting Partners?		Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Pre-mRNA Intronic Binding Histone H4 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Transcription By RNA Polymerase II Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Calcineurin-mediated Signaling Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Hemopoiesis DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Cocaine Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Gene Expression Cellular Response To Osmotic Stress Transcription Coactivator Binding Transcription Initiation-coupled Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation	Protein Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Keratin Filament Keratinization Regulation Of Gene Expression Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Activity Positive Regulation Of Biosynthetic Process Umbilical Cord Morphogenesis Pattern Specification Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Flagellated Sperm Motility Sperm Motility Myoblast Fate Commitment Positive Regulation Of Macromolecule Metabolic Process Hair Cycle Cilium-dependent Cell Motility
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